Dataset Information

Trans-tissue molecular coordination in high-intensity physical activity

ABSTRACT: High-intensity physical activity has major impacts in different parts of the body. However, the regulatory coordination between different tissues to support the high physical demands is poorly understood. Here we performed a multi-omics analysis of blood plasma, urine and saliva from a group of firefighters that underwent a 45-minute intense exercise session. The plasma analysis showed signatures of tissue damage and acute repair response. This is accompanied by lipolysis, glycolysis and amino acid degradation towards supplying the high-energetic demands. Concomitantly, the urine analysis showed a strong regulation of the renin-angiotensin system towards excretion of catabolites, reabsorption of nutrients and balance of the body fluids. The saliva showed a decrease in inflammatory molecules and increase in antimicrobial peptides, possibly towards improving the circulatory and respiratory capacity. Overall, our data show signatures of coordinated action between different organs towards supplying the demands of high-intensity physical activity.

INSTRUMENT(S): Liquid Chromatography MS - positive, Liquid Chromatography MS - negative, Gas Chromatography MS - positive

PROVIDER: MTBLS1891 | MetaboLights | 2025-07-03

REPOSITORIES: MetaboLights

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			Action	DRS
	BRAVE_FF_HPlas_101_L_01_Neg_29Aug19_Lola-WCSH417820.raw	Raw
	BRAVE_FF_HPlas_101_L_01_pos_28Aug19_Lola-WCSH417820.raw	Raw
	BRAVE_FF_HPlas_101_M_01.CDF	Other
	BRAVE_FF_HPlas_102_L_02_Neg_29Aug19_Lola-WCSH417820.raw	Raw
	BRAVE_FF_HPlas_102_L_02_pos_28Aug19_Lola-WCSH417820.raw	Raw

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Elucidating regulatory processes of intense physical activity by multi-omics analysis.

Nakayasu Ernesto S ES Gritsenko Marina A MA Kim Young-Mo YM Kyle Jennifer E JE Stratton Kelly G KG Nicora Carrie D CD Munoz Nathalie N Navarro Kathleen M KM Claborne Daniel D Gao Yuqian Y Weitz Karl K KK Paurus Vanessa L VL Bloodsworth Kent J KJ Allen Kelsey A KA Bramer Lisa M LM Montes Fernando F Clark Kathleen A KA Tietje Grant G Teeguarden Justin J Burnum-Johnson Kristin E KE

Military Medical Research 20231018 1

<h4>Background</h4>Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations, such as firefighting, law enforcement, military, and sports. A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work environment.<h4>Methods</h4>To study regulatory processes in intense physical activity simulating real-life conditions, we performed ...[more]

PMID: 37853489

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