Dataset Information

Altered milk tryptophan and tryptophan metabolites and health of children born to women with HIV (Haiti study assays).

ABSTRACT:

Children born to women with HIV (WWH) suffer increased morbidity and, in low-income settings, have two to three times the mortality of infants born to women without HIV. The basis for this increase remains elusive. In low-income settings, breastfeeding is recommended because health benefits outweigh the risk of transmission, especially when maternal antiretroviral therapy is provided. We profiled the milk metabolome of 326 women sampled longitudinally for 18 months postpartum using global metabolomics. We identify perturbations in several metabolites, including tryptophan, dimethylarginine, and a recently discovered antiviral ribonucleotide, that are robustly associated with maternal HIV infection. Quantitative tryptophan and kynurenine levels in both milk and plasma reveal that these perturbations reflect systemic depletion of tryptophan and alterations in tryptophan catabolism in WWH. Our findings provide intriguing evidence that decreases in tryptophan availability and perturbations in tryptophan catabolism in children born to WWH may contribute to their increased morbidity and mortality.

Haiti study assays are reported in the current study MTBLS2573.

ZEBS study milk assays are reported in MTBLS2307.

ZEBS study plasma assays are reported in MTBLS2572.

INSTRUMENT(S): Liquid Chromatography MS - - - Q Exactive

PROVIDER: MTBLS2573 | MetaboLights | 2025-08-26

REPOSITORIES: MetaboLights

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Dataset's files

Source:

			Action	DRS
	27054 Peak Area Table.xlsx	Xlsx
	QXA03POSEAR20231109_UCLA0623PHMD_HUMAN_MILK1_03.mzML	Mzml
	QXA03POSEAR20231109_UCLA0623PHMD_HUMAN_MILK1_04.mzML	Mzml
	QXA03POSEAR20231109_UCLA0623PHMD_HUMAN_MILK1_05.mzML	Mzml
	QXA03POSEAR20231109_UCLA0623PHMD_HUMAN_MILK1_06.mzML	Mzml

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Publications

Altered milk tryptophan and tryptophan metabolites and health of children born to women with HIV.

Tobin Nicole H NH Li Fan F Zhu Wentao W Ferbas Kathie G KG Sleasman John W JW Raftery Daniel D Kuhn Louise L Aldrovandi Grace M GM

Research square 20250321

PMID: 40166030

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