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Industrial by-products as a novel circular source of biocompatible extracellular vesicles

ABSTRACT:

Extracellular vesicles (EVs) constitute an intricate system of molecular exchange that has recently gained tremendous interest. However, sustainable sources of safe biological EVs remain scarce and elusive. In this study we explore and define the use of food industry byproducts (BP) as a circular source of safe biocompatible EVs. Averaged diameter and molecular compositions indicate large yield of exosomes and high abundancy of membrane lipids with signaling capacity in these vesicles. Complex proteomes mimicking those circulating in human blood plasma were also identified. Furthermore, BP-EVs did not show relevant cytotoxicity and displayed excellent oral and intravenous bioavailability together with specific organ targeting capacity. Collectively, we believe that the novel findings reported here will open substantial venues for the use of BP as an optimal source of biocompatible nanovesicles in manifold applications of the bioeconomy and biomedical fields.

INSTRUMENT(S): Liquid Chromatography MS - negative - reverse phase, Liquid Chromatography MS - positive - reverse phase

PROVIDER: MTBLS2801 | MetaboLights | 2022-05-17

REPOSITORIES: MetaboLights

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			Action	DRS
	neg_ASB1.d.zip	Other
	neg_ASB2.d.zip	Other
	neg_ASB3.d.zip	Other
	neg_ASM1.d.zip	Other
	neg_ASM2.d.zip	Other

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