Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA110287PRJNA105769PRJNA105767PRJNA237293PRJNA237291PRJNA237294
INSTRUMENT(S): Xevo TQ MS (Waters)
SUBMITTER: Saikumari Krishnaiah
PROVIDER: MTBLS292 | MetaboLights | 2017-04-05
REPOSITORIES: MetaboLights
Krishnaiah Saikumari Y SY Wu Gang G Altman Brian J BJ Growe Jacqueline J Rhoades Seth D SD Coldren Faith F Venkataraman Anand A Olarerin-George Anthony O AO Francey Lauren J LJ Mukherjee Sarmistha S Girish Saiveda S Selby Christopher P CP Cal Sibel S Er Ubeydullah U Sianati Bahareh B Sengupta Arjun A Anafi Ron C RC Kavakli I Halil IH Sancar Aziz A Baur Joseph A JA Dang Chi V CV Hogenesch John B JB Weljie Aalim M AM
Cell metabolism 20170401 4
The intricate connection between the circadian clock and metabolism remains poorly understood. We used high temporal resolution metabolite profiling to explore clock regulation of mouse liver and cell-autonomous metabolism. In liver, ∼50% of metabolites were circadian, with enrichment of nucleotide, amino acid, and methylation pathways. In U2 OS cells, 28% were circadian, including amino acids and NAD biosynthesis metabolites. Eighteen metabolites oscillated in both systems and a subset of these ...[more]