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A serum nuclear magnetic resonance-based metabolomic signature of antiphospholipid syndrome

ABSTRACT: Antiphospholipid syndrome (APS) is a rheumatic inflammatory chronic autoimmune disease inducing hypercoagulable state associated with vascular thrombosis and pregnancy loss in women. Cardiac, cerebral and vascular strokes in these patients are responsible for reduction in life expectancy. Timely diagnosis and accurate monitoring of disease are decisive to improve the accuracy of therapy. In the present work, we present a NMR-based metabolomic study of blood sera of APS patients. Our data show that individuals suffering APS have a characteristic metabolomic profile with abnormalities associated to the metabolism of methyl group donors, ketone bodies and amino acids. We have identified for the first time the metabolomic fingerprint characterizing APS disease having potential application to improve APS timely diagnosis and appropriate therapeutic approaches.

INSTRUMENT(S): Bruker

PROVIDER: MTBLS356 | MetaboLights | 2017-09-06

REPOSITORIES: MetaboLights

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	APS_acquisition_data.xlsx	Xlsx
	aps_d1.zip	Other
	aps_d10.zip	Other
	aps_d11.zip	Other
	aps_d12.zip	Other

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A serum nuclear magnetic resonance-based metabolomic signature of antiphospholipid syndrome.

Palisi Angelica A Grimaldi Manuela M Sabatini Paola P Montoro Paola P Scrima Mario M Rodriquez Manuela M D'Ursi Anna Maria AM

Journal of pharmaceutical and biomedical analysis 20161102

Antiphospholipid syndrome (APS) is a rheumatic inflammatory chronic autoimmune disease inducing hypercoagulable state associated with vascular thrombosis and pregnancy loss in women. Cardiac, cerebral and vascular strokes in these patients are responsible for reduction in life expectancy. Timely diagnosis and accurate monitoring of disease are decisive to improve the accuracy of therapy. In the present work, we present a NMR-based metabolomic study of blood sera of APS patients. Our data show th ...[more]

PMID: 27829500

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