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Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide

ABSTRACT: Trypanosoma brucei is the causative agent of human African trypanosomiasis, which is responsible for thousands of deaths every year. Current therapies are limited and there is an urgent need to develop new drugs. The anti-trypanosomal compound, 3-(oxazolo[4,5-b]pyridine-2-yl)anilide (OXPA), was initially identified in a phenotypic screen and subsequently optimized by structure–activity directed medicinal chemistry. It has been shown to be non-toxic and to be active against a number of trypanosomatid parasites. However, nothing is known about its mechanism of action.

INSTRUMENT(S): Exactive (Thermo Scientific)

PROVIDER: MTBLS360 | MetaboLights | 2017-10-09

REPOSITORIES: MetaboLights

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			Action	DRS
	BBlank1_DC50007.mzXML	Mzxml
	BBlank2_DC50020.mzXML	Mzxml
	BBlank3_DC50033.mzXML	Mzxml
	BBlank4_DC50046.mzXML	Mzxml
	CB1_DC50002.mzXML	Mzxml

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