Leptin increases hepatic triglyceride export via a vagal mechanism in humans
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Liquid Chromatography MS - alternating - reverse phase
SUBMITTER: Nara Marella
PROVIDER: MTBLS4231 | MetaboLights | 2023-06-07
REPOSITORIES: MetaboLights
Publications
Leptin increases hepatic triglyceride export via a vagal mechanism in humans.
Metz Matthäus M Beghini Marianna M Wolf Peter P Pfleger Lorenz L Hackl Martina M Bastian Magdalena M Freudenthaler Angelika A Harreiter Jürgen J Zeyda Maximilian M Baumgartner-Parzer Sabina S Marculescu Rodrig R Marella Nara N Hannich J Thomas JT Györi Georg G Berlakovich Gabriela G Roden Michael M Krebs Michael M Risti Robert R Lõokene Aivar A Trauner Michael M Kautzky-Willer Alexandra A Krššák Martin M Stangl Herbert H Fürnsinn Clemens C Scherer Thomas T
Cell metabolism 20221010 11
Recombinant human leptin (metreleptin) reduces hepatic lipid content in patients with lipodystrophy and overweight patients with non-alcoholic fatty liver disease and relative hypoleptinemia independent of its anorexic action. In rodents, leptin signaling in the brain increases very-low-density lipoprotein triglyceride (VLDL-TG) secretion and reduces hepatic lipid content via the vagus nerve. In this randomized, placebo-controlled crossover trial (EudraCT Nr. 2017-003014-22), we tested whether a ...[more]
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