Ontology highlight
ABSTRACT:
INSTRUMENT(S): Liquid Chromatography MS - alternating - hilic
SUBMITTER: DAN WU
PROVIDER: MTBLS4307 | MetaboLights | 2022-06-23
REPOSITORIES: MetaboLights
Huang Qichao Q Wu Dan D Zhao Jing J Yan Zeyu Z Chen Lin L Guo Shanshan S Wang Dalin D Yuan Chong C Wang Yinping Y Liu Xiaoli X Xing Jinliang J
The EMBO journal 20220422 11
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoskeleton was examined. Polymerization of nuclear actin is causally linked to the high-metastatic ability of HCC cells by modulating chromatin accessibility and coordinating the expression of genes associ ...[more]