In this study, we present the first ever population level assessment of the biochemical phenotype associated with frailty, derived from comprehensive marker measurement. Analysis of serum from 1,191 older individuals (aged between 56 and 84 years old) was carried out using gas and liquid chromatography-mass spectrometry with metabolomics and biochemistry data being stratified across a modelled frailty index. Subsequent multivariate regression and network modelling identified 25 key metabolites (including three tocotrienols and six carnitines) in the differentiation of frail and non-frail phenotypes. These findings indicate the key role that the interaction of the carnitine shuttle and vitamin E metabolism play in modulating cellular energy production in relation to risk of frailty.
INSTRUMENT(S): LTQ Orbitrap XL (Thermo Scientific)
SUBMITTER: Nicholas Rattray