Dataset Information

Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the Myc-dependent metabolic reprogramming of stromal cells

ABSTRACT: Cancer and other cells residing in the same niche engage various modes of interactions to synchronize and to buffer the negative effects of environmental changes. Extracellular miRNAs have been recently implicated in the intercellular crosstalk. Here we show a mechanistic model involving breast-cancer-secreted, extracellular-vesicle-encapsulated miR-105, which is induced by the oncoprotein MYC in cancer cells and in turn activates MYC signaling in cancer-associated fibroblasts (CAFs) to induce a metabolic program. This results in CAFs metabolic plasticity toenhance glycolysis and glutaminolysis to fuel adjacent cancer cells when nutrients are sufficient (the symbiosis mode), and detoxify metabolic wastes (lactic acid and ammonium) by converting them into energy-rich metabolites, when nutrients are deprived whereas metabolic byproducts are accumulated. This commensalism of cancer stroma emphasizes the functional flexibility of non-cancer cell populations contributing to cancer fitness during sustained growth of tumour.

INSTRUMENT(S): Nuclear Magnetic Resonance (NMR)

SUBMITTER: wei yan

PROVIDER: MTBLS626 | MetaboLights | 2018-07-10

REPOSITORIES: MetaboLights

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Dataset's files

Source:

			Action	DRS
	MTBLS626	Other
	FILES	Other
	a_MTBLS626_metabolite_profiling_NMR_spectroscopy.txt	Txt
	i_Investigation.txt	Txt
	m_MTBLS626_metabolite_profiling_NMR_spectroscopy_v2_maf.tsv	Tabular

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Publications

Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells.

Yan Wei W Wu Xiwei X Zhou Weiying W Fong Miranda Y MY Cao Minghui M Liu Juan J Liu Xiaojing X Chen Chih-Hong CH Fadare Oluwole O Pizzo Donald P DP Wu Jiawen J Liu Liang L Liu Xuxiang X Chin Andrew R AR Ren Xiubao X Chen Yuan Y Locasale Jason W JW Wang Shizhen Emily SE

Nature cell biology 20180416 5

Cancer and other cells residing in the same niche engage various modes of interactions to synchronize and buffer the negative effects of environmental changes. Extracellular microRNAs (miRNAs) have recently been implicated in the intercellular crosstalk. Here we show a mechanistic model involving breast-cancer-secreted, extracellular-vesicle-encapsulated miR-105, which is induced by the oncoprotein MYC in cancer cells and, in turn, activates MYC signalling in cancer-associated fibroblasts (CAFs) ...[more]

PMID: 29662176

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