Ontology highlight
ABSTRACT:
INSTRUMENT(S): Liquid Chromatography MS - negative - reverse phase
SUBMITTER: Elite Possik
PROVIDER: MTBLS6847 | MetaboLights | 2024-02-07
REPOSITORIES: MetaboLights
Possik Elite E Klein Laura-Lee LL Sanjab Perla P Zhu Ruyuan R Côté Laurence L Bai Ying Y Zhang Dongwei D Sun Howard H Al-Mass Anfal A Oppong Abel A Ahmad Rasheed R Parker Alex A Madiraju S R Murthy SRM Al-Mulla Fahd F Prentki Marc M
Nature communications 20230825 1
Metabolic stress caused by excess nutrients accelerates aging. We recently demonstrated that the newly discovered enzyme glycerol-3-phosphate phosphatase (G3PP; gene Pgp), which operates an evolutionarily conserved glycerol shunt that hydrolyzes glucose-derived glycerol-3-phosphate to glycerol, counters metabolic stress and promotes healthy aging in C. elegans. However, the mechanism whereby G3PP activation extends healthspan and lifespan, particularly under glucotoxicity, remained unknown. Here ...[more]