Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Metabolomic profiling of jejunal samples from ETEC-challenged yak calves supplemented with Pediococcus pentosaceus NQ0729

ABSTRACT:

This study generated metabolomic data to investigate metabolic changes in yak calves following enterotoxigenic Escherichia coli (ETEC) challenge and Pediococcus pentosaceus NQ0729 supplementation. Yak calves were divided into three groups: a control group (CON), an ETEC-challenged group (ETEC), and a P. pentosaceus NQ0729-pretreated group followed by ETEC challenge (PET). Jejunal samples were collected after the animal trial and analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The dataset was used to compare metabolic profiles among the three groups and to identify metabolites and metabolic pathways associated with ETEC challenge and probiotic intervention in yak calves.

INSTRUMENT(S): Liquid Chromatography MS - negative - reverse-phase, Liquid Chromatography MS - positive - reverse-phase

PROVIDER: MTBLS8030 | MetaboLights | 2026-06-06

REPOSITORIES: MetaboLights

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	a_MTBLS8030_LC-MS_negative_reverse-phase.txt	Txt
	a_MTBLS8030_LC-MS_positive_reverse-phase.txt	Txt
	i_Investigation.txt	Txt
	m_MTBLS8030_LC-MS_negative_reverse-phase_v2_maf.tsv	Tabular
	m_MTBLS8030_LC-MS_positive_reverse-phase_v2_maf.tsv	Tabular

Items per page:

1 - 5 of 6

Similar Datasets

Proteomic profiling of jejunal tissues from ETEC-challenged yak calves supplemented with Pediococcus pentosaceus NQ0729

Project description:This study generated quantitative proteomic data to investigate protein expression changes in the jejunum of yak calves following enterotoxigenic Escherichia coli (ETEC) challenge and Pediococcus pentosaceus NQ0729 supplementation. Yak calves were divided into three groups: a control group (CON), an ETEC-challenged group (ETEC), and a P. pentosaceus NQ0729-pretreated group followed by ETEC challenge (PET). Jejunal tissue samples were collected at the end of the animal trial and analyzed using LC-MS/MS-based quantitative proteomics. The dataset was used to compare protein abundance profiles among the three groups and to identify differentially expressed proteins and enriched biological pathways associated with ETEC challenge and probiotic intervention in yak calves.

2026-06-06 | PXD079365 |

Transcriptomic profiling of jejunal tissues from ETEC-challenged yak calves supplemented with Pediococcus pentosaceus NQ0729

Project description:This study generated transcriptomic data to investigate gene expression changes in the jejunum of yak calves following enterotoxigenic Escherichia coli (ETEC) challenge and Pediococcus pentosaceus NQ0729 supplementation.

2026-06-12 | GSE334624 | GEO

ruminal contents in yak calves

Project description:ruminal contents in yak calves Targeted loci environmental

| PRJNA809113 | ENA

Changes in the Abundance of the Fecal Microbiota are Implicated in the Pathogenesis of Diarrhea in Yak Calves

Project description:<p>The yak, an economically vital species on the Qinghai-Tibet Plateau, faces a significant challenge with diarrhea during the calf stage. However, studies about diarrhea of yak calves were few. Due to the close link between diarrhea and intestinal microbiota. Therefore, this study analyzed the fecal microbiota in diarrheic and healthy yak calves, and using a pseudo germ-free (PGF) mouse model to investigate the causes for diarrhea. This study identified microbial dysbiosis in diarrheic yak calves, characterized by significant enrichment of Ruminococcus gnavus and Streptococcus.</p>

2026-06-03 | MTBLS13964 | MetaboLights

Transcriptomic Analysis of the Host Response and Innate Resilience to Enterotoxigenic Escherichia coli Infection in Humans

Project description:Enterotoxigenic Escherichia coli (ETEC) is a globally prevalent cause of diarrhea. We report the first gene expression analysis of the human host response to experimental challenge with ETEC.

2017-02-22 | GSE95104 | GEO

Intestinal proteomic response to oral challenge of enterotoxigenic Escherichia coli in weaned pigs

Project description:Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhoea in children in resource-limited countries and of travellers diarrhoea. The ileal proteomics change after ETEC challenge is less characterised. Here in this study changes of ileal proteins post ETEC challenge in weaned pigs are studied. In total, 5151 ileal proteins were successfully annotated and 9 proteins had significantly different abundance between the ETEC and CON pigs.

2022-04-01 | PXD028066 | Pride

The transcriptome sequencing of yak (Bos grunniens)

Project description:Deep sequencing of mRNA from 6 organs of yak (Bos grunniens) Analysis of ploy(A)+ RNA of brain,heart,liver,lung,spleen, and stomach of yak (Bos grunniens)

2012-05-18 | E-GEOD-33300 | biostudies-arrayexpress

The MAIT cell response to controlled oral enterotoxigenic E. coli challenge

Project description:Mucosa-associated invariant T (MAIT) cells recognize conserved microbial antigens presented by the non-polymorphic MR1 molecules and play important roles in barrier immunity. Enterotoxigenic E. coli (ETEC) is a major cause of diarrheal disease especially among children in lower-income countries. Here we investigate the potential role of MAIT cells in ETEC infection using samples from a human experimental ETEC challenge study. MAIT cells were activated with elevated function and proliferation in blood on day 7 after challenge, reflected both at protein and transcript levels, a pattern most evident among individuals who developed mild to severe diarrhea (MSD). The MSD-positive group had elevated expression of CCR9 and α4β7 on MAIT cells and experienced expansion of the peripheral MAIT cell pool at day 28 after challenge. Finally, the size of the MAIT cell pool correlated with MSD disease severity score. These findings indicate that MAIT cells respond to ETEC infection in a way associated with the development of symptomatic disease.

2025-05-20 | GSE276378 | GEO

Transcriptomic profiling of jejunal tissues from ETEC-challenged yak calves supplemented with Pediococcus pentosaceus NQ0729

Project description:Transcriptomic profiling of jejunal tissues from ETEC-challenged yak calves supplemented with Pediococcus pentosaceus NQ0729

| PRJNA1476049 | ENA

Molecular and immunological interrogation of a live-attenuated enterotoxigenic Escherichia coli vaccine highlights features unique to wild type infection

Project description:Enterotoxigenic Escherichia coli (ETEC) infections are a common cause of diarrheal illness in low- and middle-income countries. The live-attenuated ACE527 vaccine, adjuvanted with double mutant LT (dmLT), affords clear but partial protection against ETEC challenge inhuman volunteers. Comparatively, initial wild-type ETEC challenge completely protects against severe diarrhea on homologous re-challenge...To investigate molecular determinants of protection, vaccine antigen content was compared to wild-type ETEC, and proteome microarrays were used to assess immune responses following vaccination and ETEC challenge... Although molecular interrogation of the vaccine confirmed expression of targeted canonical antigens, relative to wild-type ETEC, vaccine strains were deficient in production of flagellar antigens, immotile, and lacked production of the EtpA adhesin. Similarly, vaccination ± dmLT elicited responses to targeted canonical antigens, but relative to wild-type challenge, vaccine responses to some potentially protective non-canonical antigens including EtpA were diminished or absent...These studies highlight important differences in vaccine and wild-type ETEC antigen content and call attention to distinct immunologic signatures that could inform investigation of correlates of protection, and guide vaccine antigen selection for these pathogens of global importance.

2019-07-25 | GSE134792 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data