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Large-scale non-targeted serum metabolomics in the Prospective Investigation of the Vasculature in Uppsala Seniors

ABSTRACT: The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) is a community-based study where all men and women at age 70 living in Uppsala, Sweden were invited to participate in 2001. The 1,016 participants (50% women) have been extensively phenotyped. In March 2006 a reinvesigation of the cohort at the age of 75 was started. The major measurements performed at age 70 were also repeated at age 75. Here we make publically available all the metabolomics analysis on serum samples from the investigation at age 70. In the final analysis we included samples from 968 individuals.

OTHER RELATED OMICS DATASETS IN: PXD002377

INSTRUMENT(S): Xevo G2 QTOF (Waters)

SUBMITTER: Andrea Ganna

PROVIDER: MTBLS90 | MetaboLights | 2014-08-30

REPOSITORIES: MetaboLights

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Large-scale metabolomic profiling identifies novel biomarkers for incident coronary heart disease.

Ganna Andrea A Salihovic Samira S Sundström Johan J Broeckling Corey D CD Hedman Asa K AK Magnusson Patrik K E PK Pedersen Nancy L NL Larsson Anders A Siegbahn Agneta A Zilmer Mihkel M Prenni Jessica J Arnlöv Johan J Lind Lars L Fall Tove T Ingelsson Erik E

PLoS genetics 20141211 12

Analyses of circulating metabolites in large prospective epidemiological studies could lead to improved prediction and better biological understanding of coronary heart disease (CHD). We performed a mass spectrometry-based non-targeted metabolomics study for association with incident CHD events in 1,028 individuals (131 events; 10 y. median follow-up) with validation in 1,670 individuals (282 events; 3.9 y. median follow-up). Four metabolites were replicated and independent of main cardiovascula ...[more]

PMID: 25502724

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