Dataset Information

Large-scale non-targeted serum metabolomics in the Swedish Twin Registry

ABSTRACT: The TwinGene project, conducted between 2004 and 2008, is a population-based Swedish study of twins born between 1911 and 1958. The study participants have previously participated in a telephone interview called Screening Across the Lifespan Twin Study, conducted between 1998 and 2002. To be included in TwinGene, both twins within a pair had to be alive. In total, 12591 individuals participated by donating blood to the study, and by answering questionnaires about life style and health. For the purpose of metabolomic profiling, we designed a case-cohort of incident coronary heart disease, diabetes, dementia and ischemic stroke events and a matched sub-cohort (controls) stratified on age and sex. In the final analysis we included serum samples from 2,139 individuals.

INSTRUMENT(S): Xevo G2 QTOF (Waters)

PROVIDER: MTBLS93 | MetaboLights | 2014-08-30

REPOSITORIES: MetaboLights

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	021228_TwinGene_000101.CDF	Other
	021228_TwinGene_000102.CDF	Other
	021228_TwinGene_000201.CDF	Other
	021228_TwinGene_000202.CDF	Other
	021228_TwinGene_000301.CDF	Other

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Publications

The Swedish Twin Registry: establishment of a biobank and other recent developments.

Magnusson Patrik K E PK Almqvist Catarina C Rahman Iffat I Ganna Andrea A Viktorin Alexander A Walum Hasse H Halldner Linda L Lundström Sebastian S Ullén Fredrik F Långström Niklas N Larsson Henrik H Nyman Anastasia A Gumpert Clara Hellner CH Råstam Maria M Anckarsäter Henrik H Cnattingius Sven S Johannesson Magnus M Ingelsson Erik E Klareskog Lars L de Faire Ulf U Pedersen Nancy L NL Lichtenstein Paul P

Twin research and human genetics : the official journal of the International Society for Twin Studies 20121109 1

The Swedish Twin Registry (STR) today contains more than 194,000 twins and more than 75,000 pairs have zygosity determined by an intra-pair similarity algorithm, DNA, or by being of opposite sex. Of these, approximately 20,000, 25,000, and 30,000 pairs are monozygotic, same-sex dizygotic, and opposite-sex dizygotic pairs, respectively. Since its establishment in the late 1950s, the STR has been an important epidemiological resource for the study of genetic and environmental influences on a multi ...[more]

PMID: 23137839

Publication: 1/2

Dataset Information

Large-scale non-targeted serum metabolomics in the Swedish Twin Registry

Dataset's files

Publications

The Swedish Twin Registry: establishment of a biobank and other recent developments.

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