Dataset Information

Large-scale non-targeted serum metabolomics in the Swedish Twin Registry

ABSTRACT: The TwinGene project, conducted between 2004 and 2008, is a population-based Swedish study of twins born between 1911 and 1958. The study participants have previously participated in a telephone interview called Screening Across the Lifespan Twin Study, conducted between 1998 and 2002. To be included in TwinGene, both twins within a pair had to be alive. In total, 12591 individuals participated by donating blood to the study, and by answering questionnaires about life style and health. For the purpose of metabolomic profiling, we designed a case-cohort of incident coronary heart disease, diabetes, dementia and ischemic stroke events and a matched sub-cohort (controls) stratified on age and sex. In the final analysis we included serum samples from 2,139 individuals.

INSTRUMENT(S): Xevo G2 QTOF (Waters)

SUBMITTER: Andrea Ganna

PROVIDER: MTBLS93 | MetaboLights | 2014-08-30

REPOSITORIES: MetaboLights

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Publications

The Swedish Twin Registry: establishment of a biobank and other recent developments.

Magnusson Patrik K E PK Almqvist Catarina C Rahman Iffat I Ganna Andrea A Viktorin Alexander A Walum Hasse H Halldner Linda L Lundström Sebastian S Ullén Fredrik F Långström Niklas N Larsson Henrik H Nyman Anastasia A Gumpert Clara Hellner CH Råstam Maria M Anckarsäter Henrik H Cnattingius Sven S Johannesson Magnus M Ingelsson Erik E Klareskog Lars L de Faire Ulf U Pedersen Nancy L NL Lichtenstein Paul P

Twin research and human genetics : the official journal of the International Society for Twin Studies 20121109 1

The Swedish Twin Registry (STR) today contains more than 194,000 twins and more than 75,000 pairs have zygosity determined by an intra-pair similarity algorithm, DNA, or by being of opposite sex. Of these, approximately 20,000, 25,000, and 30,000 pairs are monozygotic, same-sex dizygotic, and opposite-sex dizygotic pairs, respectively. Since its establishment in the late 1950s, the STR has been an important epidemiological resource for the study of genetic and environmental influences on a multi ...[more]

PMID: 23137839

Publication: 1/2

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Project description:Background Many environmental and lifestyle factors have been implicated in the decline of sperm quality, with diet being one of the most plausible factors identified in recent years. Moreover, several studies have reported a close association between the alteration of specific sperm DNA methylation signatures and semen quality. Objectives To evaluate the effect of tree nuts consumption on sperm DNA methylation patterns in healthy individuals reporting eating a Western‐style diet. Material and Methods This is a post‐hoc analysis conducted in a subset of participants (healthy, non‐smoking, and young) from the FERTINUTS 14‐wk randomized‐controlled, parallel‐trial, recruited between December 2015 and February 2017. The participants included in the current study (n=72) were randomly selected in a proportion 2:1 from the original FERTINUTS trial between the 98 participants that completed the entire dietary intervention (nut group, n=48; control group, n=24). Sperm DNA methylation patterns were examined at baseline and after 14 weeks in 48 individuals consuming 60 g/d of mixed nuts (nuts group) and in 24 individuals following the usual Western‐style diet avoiding consumption of nuts (control group). Results Over the course of the trial, no significant changes in global methylation were observed between groups. However, in the nuts group, we identified 36 genomic regions that were significantly differentially methylated between the baseline and the end of the trial and 97.2% of the regions displayed hypermethylation. We identified no such change in the control group over the same period of time. We also utilized the recently developed germ line age calculator to determine if nut consumption resulted in alterations to the epigenetic age of cells and no significant differences were found. Discussion and Conclusion Adding nuts to a regular Western‐style diet subtly impacts sperm DNA methylation in specific regions, demonstrating that there are some sperm epigenome regions that could respond to diet.

Dataset Information

Large-scale non-targeted serum metabolomics in the Swedish Twin Registry

Publications

The Swedish Twin Registry: establishment of a biobank and other recent developments.

Similar Datasets

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