Metabolomics

Dataset Information

10

Effects of Platycodins Folium on Depression in Mice Based on a UPLC-Q/TOF-MS Serum Assay and Hippocampus Metabolomics.


ABSTRACT: Major depressive disorder (MDD), also known as depression, is a state characterized by low mood and aversion to activity. Platycodins Folium (PF) is the dried leaf of Platycodon grandiflorum, with anti-inflammatory and antioxidative activities. Our previous research suggested that PF was rich in flavonoids, phenols, organic acids, triterpenoid saponins, coumarins and terpenoids. This study aimed to investigate the antidepressant effect of PF using lipopolysaccharide (LPS)-induced depressive mice. Several behavior tests (sucrose preference test (SPT), forced swimming test (FST) and tail suspension test (TST)) and biochemical parameters (IL-6, TNF-α and SOD levels) were used to evaluate the antidepressive effect of PF on LPS-induced depression model. Furthermore, a UPLC-Q/TOF-MS-based metabolomics approach was applied to explore the latent mechanism of PF in attenuating depression. As a result, a total of 21 and 11 metabolites that potentially contribute to MDD progress and PF treatment were identified in serum and hippocampus, respectively. The analysis of metabolic pathways revealed that lipid metabolism, amino acid metabolism, energy metabolism, arachidonic acid metabolism, glutathione metabolism and inositol phosphate metabolism were disturbed in a model of mice undergoing MDD and PF treatment. These results help us to understand the pathogenesis of depression in depth, and to discover targets for clinical diagnosis and treatment. They also provide the possibility of developing PF into an anti-depressantive agent.

INSTRUMENT(S): Liquid Chromatography MS - Negative (LC-MS (Neg)), Liquid Chromatography MS - Positive (LC-MS (Pos))

SUBMITTER: Jinping Liu  

PROVIDER: MTBLS952 | MetaboLights | 2020-06-03

REPOSITORIES: MetaboLights

Dataset's files

Source:
Action DRS
MTBLS952 Other
a_MTBLS952_NEG_Hippo_LC-MS.txt Txt
a_MTBLS952_NEG_Serum_LC-MS.txt Txt
a_MTBLS952_POS_Hippo_LC-MS.txt Txt
a_MTBLS952_POS_Serum_LC-MS.txt Txt
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Publications

Effects of Platycodins Folium on Depression in Mice Based on a UPLC-Q/TOF-MS Serum Assay and Hippocampus Metabolomics.

Wang Cuizhu C   Lin Hongqiang H   Yang Na N   Wang Han H   Zhao Yan Y   Li Pingya P   Liu Jinping J   Wang Fang F  

Molecules (Basel, Switzerland) 20190502 9


Major depressive disorder (MDD), also known as depression, is a state characterized by low mood and aversion to activity. Platycodins Folium (PF) is the dried leaf of Platycodon grandiflorum, with anti-inflammatory and antioxidative activities. Our previous research suggested that PF was rich in flavonoids, phenols, organic acids, triterpenoid saponins, coumarins and terpenoids. This study aimed to investigate the antidepressant effect of PF using lipopolysaccharide (LPS)-induced depressive mice  ...[more]

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