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Proteolethargy is a pathogenic mechanism in chronic disease

ABSTRACT:

The pathogenic mechanisms of many diseases are well understood at the molecular level, but there are prevalent diseases associated with pathogenic signaling, such as diabetes and chronic inflammatory disorders, where our understanding is more limited. Here we report that pathogenic signaling suppresses the mobility of a spectrum of proteins that play essential roles in cellular functions known to be dysregulated in these chronic diseases. This behavior was linked to cysteine residues in the affected proteins and signaling-related increases in excess reactive oxygen species. Diverse pathogenic stimuli, including hyperglycemia, dyslipidemia and inflammation, produce similar suppressed protein mobility phenotypes. We propose that suppressed protein mobility may account for various pathogenic features of diverse chronic diseases.

INSTRUMENT(S): Liquid Chromatography MS - alternating - hilic

PROVIDER: MTBLS9535 | MetaboLights | 2024-08-09

REPOSITORIES: MetaboLights

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			Action	DRS
	H2O2_curve_GSSG_vs_GSH.xlsx	Xlsx
	Job2803_normal_v_patho_all_metabolites.xlsx	Xlsx
	Job2811_H2O2_curve_all_metabolites.xlsx	Xlsx
	Normal_vs_Patho_GSSG_vs_GSH.xlsx	Xlsx
	20230818_QE2_SM_Job2803_19.raw	Raw

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Proteolethargy is a pathogenic mechanism in chronic disease

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