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Metabolite levels in lung and prostate cancer cells compared to normal tissue.

ABSTRACT: Metabolite levels in lung and prostate cancer cells compared to normal tissue.

INSTRUMENT(S): 1D-CE-ESI-TOF-MS

SUBMITTER: Adam J. Carroll

PROVIDER: MEX66 | MetabolomeExpress | 2012-11-02

REPOSITORIES: MetabolomeExpress

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Metabolomic profiling of lung and prostate tumor tissues by capillary electrophoresis time-of-flight mass spectrometry.

Kami Kenjiro K Fujimori Tamaki T Sato Hajime H Sato Mutsuko M Yamamoto Hiroyuki H Ohashi Yoshiaki Y Sugiyama Naoyuki N Ishihama Yasushi Y Onozuka Hiroko H Ochiai Atsushi A Esumi Hiroyasu H Soga Tomoyoshi T Tomita Masaru M

Metabolomics : Official journal of the Metabolomic Society 20121102 2

Metabolic microenvironment of tumor cells is influenced by oncogenic signaling and tissue-specific metabolic demands, blood supply, and enzyme expression. To elucidate tumor-specific metabolism, we compared the metabolomics of normal and tumor tissues surgically resected pairwise from nine lung and seven prostate cancer patients, using capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS). Phosphorylation levels of enzymes involved in central carbon metabolism were also quantifie ...[more]

PMID: 23543897

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