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IDH1R132H activity in glioma cell lines and tumnor tissue (2HG)

ABSTRACT: We developed genetically engineered mice to generate brain tumors with especific genetic lessions. The animals were split in three groups: NRAS, P53 knockdown, IDH1-R132H and ATRX knock down (NPAID); NRAS, P53 knockdown, IDH1-R132H (NPI); NRAS, P53 knockdown, (NshP53). From these tumor we obtain and culture tumor cells growth like neurospheres and attached cells.

ORGANISM(S): Mouse Mus Musculus

TISSUE(S): Cells

DISEASE(S): Cancer

SUBMITTER: Maureen Kachman

PROVIDER: ST000312 | MetabolomicsWorkbench | Thu Mar 05 00:00:00 GMT 2015

REPOSITORIES: MetabolomicsWorkbench

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