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Metabolomics Approach to Allograft Assessment in Liver Transplantation

ABSTRACT: This pilot study is designed to apply several types of metabolomic analysis for liver allograft assessment with the aim of identifying candidate biomarkers for allograft function and to develop a methodology that could be applied to larger scale studies. The three main categories of metabolomic analysis are reflected in each of the specific aims, including a targeted profiling of central carbon metabolism, open lipidomic and metabolomic profiling for hypothesis generation and MALDI-IMS for tissue-based spatial analysis. Each of these approaches offers potential benefits that could be optimized in a protocol for larger scale studies depending the results of the pilot investigations.

ORGANISM(S): Human Homo Sapiens

TISSUE(S): Liver

DISEASE(S): Organ Transplantation

SUBMITTER: John Seal

PROVIDER: ST000337 | MetabolomicsWorkbench | Sun Jan 17 00:00:00 GMT 2016

REPOSITORIES: MetabolomicsWorkbench

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