Project description:Males and females from each SM/J and LG/J were placed on either a low-fat diet or high-fat diet immediately after weaning until 20 weeks of age. At 20 weeks, mice were sacrificed in late morning after a four-hour fast and liver tissue was collected from 4 males and 4 females from each strain and diet.
Project description:We used the BALB/c3T3 cell line model to correlate citotoxicity and transformation endpoints to expression gene profiles after IR exposure. Citotoxicity and Cell Transformation Assay (CTA) were performed 20h after IR exposure by using BALB/c3T3 cells.<br>At the same time, RNAs of exposed cells to a low dose (0.25Gy) and to a high dose (3Gy) were extracted for microarray experiments.