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Myocardial Rev-erb-mediated diurnal metabolic rhythm (Part 2/3)

ABSTRACT: Agonists and antagonists of nuclear receptor Rev-erbα/β, key components of the circadian clock, can benefit the heart. Here, we show that mice with cardiomyocyte-specific knockout (KO) of Rev-erbα/β display progressive cardiac dilation and lethal heart failure. Inducible ablation of Rev-erbα/β in adult hearts causes similar phenotypes. Impaired fatty acid oxidation in the KO myocardium, particularly in the light cycle, precedes contractile dysfunctions with a reciprocal overreliance on carbohydrate utilization, particularly in the dark cycle. These findings delineate temporal coordination between clock-mediated anticipation and nutrient-induced response in myocardial metabolism.

ORGANISM(S): Mouse Mus Musculus

TISSUE(S): Heart

SUBMITTER: Shiyang Song

PROVIDER: ST001916 | MetabolomicsWorkbench | Fri Sep 10 00:00:00 BST 2021

REPOSITORIES: MetabolomicsWorkbench

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