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Glutaminase inhibition impairs CD8 T cell activation in STK11/Lkb1 deficient lung cancer

ABSTRACT: To characterize the impact of KRAS co-mutations KEAP1 and STK11/Lkb1 on the metabolic and immune microenvironment of lung adenocarcinoma in immune-intact models, we generated a cohort of genetically engineered mouse models (GEMMs) to reflect the diverse tumor suppressor landscape seen in patients. Mice carrying the KrasG12D allele (K)21 were crossed with Keap1flox/flox (KK)22 and/or Lkb1flox/flox (KKL, KL)23 mice and genetic recombination induced by intranasal inhalation of Ad5-CMV-Cre adenovirus. We interrogated the metabolites present in lung tumor nodules collected from cohorts of KK, KL and KKL mice.

ORGANISM(S): Mouse Mus Musculus

TISSUE(S): Lung

DISEASE(S): Cancer

SUBMITTER: Best Sarah

PROVIDER: ST002066 | MetabolomicsWorkbench | Tue Jan 18 00:00:00 GMT 2022

REPOSITORIES: MetabolomicsWorkbench

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