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Metabolic signature of C-protein induced myositis mouse model

ABSTRACT: Objective of this study was to find Metabolic signature of C-protein induced myositis mouse model. For metabolite quantification, we used the tissue samples of C-protein induced myositis mouse model and control. Biocrates p180 kit enables to quantify 188 metabolites including amino acids, biogenic amines, acylcarnitine, glycerophospholipid and sugar. Significant metabolites were selected by t-test with false discovery rate p-value less than 0.05. In mouse tissue sample, a total of 68 metabolites significantly changed in CIM mice. We did pathway analysis to find altered pathway in muscle tissue. Metabolites from polyamine and beta-alanine pathway were altered.

ORGANISM(S): Mouse Mus Musculus

TISSUE(S): Muscle

DISEASE(S): Inflammation

SUBMITTER: Jihyun Kang

PROVIDER: ST002197 | MetabolomicsWorkbench | Wed Jun 15 00:00:00 BST 2022

REPOSITORIES: MetabolomicsWorkbench

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