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The impact of IgE in gut and serum metabolomes in a murine experimental model of allergic enteritis

ABSTRACT: The pathological mechanism of the gastrointestinal forms of food allergies is less understood in comparison to other clinical phenotypes, such as asthma, and anaphylaxis, partly due to difficulty in the access to intestinal tissues and because of a highly complex interplay between microbiota and intestinal mucosa. Importantly, a high level of IgE is a poor prognostic factor in gastrointestinal allergies. This study aimed to investigate how IgE influences the development of intestinal inflammation and the metabolome in allergic enteritis (AE), using IgE knock-in (IgEki) mice expressing high levels of IgE. Ovalbumin-sensitized and egg-white diet fed (OVA/EW) BALB/c WT mice developed moderate AE, whereas OVA/EW IgEki mice induced more aggravated intestinal inflammation with enhanced eosinophil accumulation.

ORGANISM(S): Mouse Mus Musculus

TISSUE(S): Feces, Blood

DISEASE(S): Allergy

SUBMITTER: Elisa Zubeldia-Varela

PROVIDER: ST002236 | MetabolomicsWorkbench | Tue Jul 19 00:00:00 BST 2022

REPOSITORIES: MetabolomicsWorkbench

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