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The impact of myriocin and dietary serine restriction on paw skin sphingolipid diversity

ABSTRACT: We analyzed paw skin polar and lipid metabolites in mice (C57BL/6J) in response to two dietary interventions. The first was: 1) low fat (LFD), 2) serine/glycine-free LFD (-SG LFD), high fat (HFD), and serine/glycine-free HFD (-SG HFD). And the second was: 1) low fat (LFD), high fat (HFD), serine/glycine-free HFD (-SG HFD), and serine/glycine-free HFD (-SG HFD) with myriocin (0.3 mg/kg every other day) treatment. The goal of the study was to determine the impact of dietary serine/glycine restriction and myriocin treatment on the hepatic lipidome.

ORGANISM(S): Mouse Mus Musculus

TISSUE(S): Skin

SUBMITTER: Michal Handzlik

PROVIDER: ST002343 | MetabolomicsWorkbench | Fri Nov 11 00:00:00 GMT 2022

REPOSITORIES: MetabolomicsWorkbench

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