Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Quartet_WGS_XTen at NVG

ABSTRACT: quartet_WGS_XTen at NVG

TISSUE(S): ['cell Line']

SUBMITTER: Ying Yu

PROVIDER: OEX00003715 | NODE | 2021-05-07

REPOSITORIES: NODE

ACCESS DATA

Json Xml

Similar Datasets

Proteomic Analysis of Aqueous Humor Identified Clinically Relevant Molecular Targets for Neovascular Complications in Diabetic Retinopathy

Project description:Diabetic retinopathy (DR) is a leading cause of blindness in adults under 40 in the developed world, with a significant proportion progressing to vision-threatening stages like proliferative diabetic retinopathy (PDR) and neovascular glaucoma (NVG). This study aims to explore the molecular mechanisms underlying the progression from non-proliferative DR (NPDR) to PDR and NVG, focusing on identifying potential biomarkers and therapeutic targets. We utilized discovery-based proteomics, specifically label free quantification (LFQ), to analyze aqueous humor (AH) proteins from patients with NPDR, PDR, and NVG from the AH samples obtained during cataract surgery or anterior chamber paracentesis. We employed triple quadrupole (QQQ)-MS for targeted protein quantification to validate marker proteins for each disease state. Notably,subsequent analyses revealed specific proteins associated with each stage of DR. Gene ontology analysis and functional annotation unveiled significant processes in DR such as immune response and lipid metabolic process. Validation of potential biomarkers revealed proteins showing significant concentration changes, with several candidates demonstrating diagnostic potential through ROC curve analysis. These findings provide insights into the biomarkers and pathogenesis of these severe neovascular complications. The identification of specific proteins associated with the progression of DR to more advanced stages offer a promising avenue for early diagnosis and targeted therapy. The study underscores the potential of AH proteomics in understanding complex diseases like DR and its complications.

2025-05-01 | PXD058481 | Pride

Proteome characterization of glaucoma aqueous humour

Project description:This work describes a proteomic analysis for different types of glaucoma (PACG, NVG) and age-related cataract as control. The AH samples were recruited from 175 individual patients with PACG, NVG and age-related cataract. First, in discovery cohort the AH proteome characteristics of PAACG, PCACG and NVG with cataract were compared by DIA approach. Second, AH proteomic features of three types of glaucoma, PAACG, PCACG and NVG, were mutually compared. In validation cohort the key proteins of above comparison were validated by PRM approach.

2021-08-02 | PXD027686 |

HCC1395_WGS_NVG

Project description:NVG

2024-09-18 | OEX00027220 | NODE

Proteomic study of aqueous humor and its application in the treatment of neovascular glaucoma

Project description:We provided a comprehensive AH proteome analysis, and expanded the profile of human AH proteome. The differential AH proteomic analysis of NVG treatment indicated that AH proteome can reflect the pathophysiological changes in drug intervention.

| PXD020177 |

quartet_DNA_WGS_Pabio-Sequel_NOM/NVG

Project description:quartet_DNA_WGS_Pabio-Sequel_NOM/NVG

2023-04-21 | OEX00014834 | NODE

quartet_methylation_WGBS at NVG

Project description:quartet_methylation_WGBS at NVG

2023-04-21 | OEX00020470 | NODE

quartet_WGS_Nova at NVG

Project description:quartet_WGS_Nova at NVG

2021-05-05 | OEX00003710 | NODE

Whole genome bisulfite sequencing of liver samples of five mammals (human, rhesus macaque, mouse, rat and dog)

Project description:This study aims to investigate the DNA methylation patterns at transcription factor binding regions and their evolutionary conservation with respect to binding activity divergence. We combined newly generated bisulfite-sequencing experiments in livers of five mammals (human, macaque, mouse, rat and dog) and matched publicly available ChIP-sequencing data for five transcription factors (CEBPA, HNF4a, CTCF, ONECUT1 and FOXA1). To study the chromatin contexts of TF binding subjected to distinct evolutionary pressures, we integrated publicly available active promoter, active enhancer and primed enhancer calls determined by profiling genome wide patterns of H3K27ac, H3K4me3 and H3K4me1.

2022-10-20 | E-MTAB-11946 | biostudies-arrayexpress

Whole genome sequencing of the Arabidopsis thaliana dot5-1 transposon insertion line

Project description:Whole genome sequencing of the Arabidopsis thaliana dot5-1 transposon insertion line described in Petricka et al 2008 The Plant Journal 56(2): 251-263.

2022-08-07 | E-MTAB-12010 | biostudies-arrayexpress

ChIP-seq of HCC1806 cells (H2Bub1, H3K79me3, H3K27ac), treated with siControl or siRNF40 for 48 hours

Project description:The analysis identifies differentially occupied genomic regions of H2Bub1, H3K79me3, and H3K27ac by RNF40 silencing in HCC1806 cells

2023-07-20 | E-MTAB-12000 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data