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Retinoblastoma samples RNA-seq

ABSTRACT: Retinoblastoma(3 tumor versus 3 para-tumor samples) RNA-sequencing

OTHER RELATED OMICS DATASETS IN: PRJNA436090

SUBMITTER: Peiwei,Chai

PROVIDER: OEX000106 | NODE |

REPOSITORIES: NODE

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Dynamic chromosomal tuning of a novel GAU1 lncing driver at chr12p13.32 accelerates tumorigenesis.

Chai Peiwei P Jia Ruobing R Jia Renbing R Pan Hui H Wang Shaoyun S Ni Hongyan H Wang Huixue H Zhou Chuandi C Shi Yingyun Y Ge Shengfang S Zhang He H Fan Xianqun X

Nucleic acids research 20180701 12

Aberrant chromatin transformation dysregulates gene expression and may be an important driver of tumorigenesis. However, the functional role of chromosomal dynamics in tumorigenesis remains to be elucidated. Here, using in vitro and in vivo experiments, we reveal a novel long noncoding (lncing) driver at chr12p13.3, in which a novel lncRNA GALNT8 Antisense Upstream 1 (GAU1) is initially activated by an open chromatin status, triggering recruitment of the transcription elongation factor TCEA1 at ...[more]

PMID: 29741668

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