Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MP

ABSTRACT: MP

SUBMITTER: Liangting Liu

PROVIDER: OEX00019150 | NODE | 2022-06-25

REPOSITORIES: NODE

ACCESS DATA

Json Xml

Similar Datasets

Human monoclonal antibodies to M. tuberculosis arabinomannan recognize distinct glycan epitopes - implications for TB diagnostics and research

Project description:Human antibody responses to AM/LAM are heterogenous and knowledge of reactivity to specific glycan epitopes at the monoclonal level is limited. Using novel glycan arrays, we characterized very high affinity monoclonal antibodies to AM/LAM, determined these mAbs are non-competing, and recognized distinct glycan epitopes. distinct from other anti-AM/LAM mAbs reported.

2021-07-21 | GSE180517 | GEO

GABPα and CREB1 binding to double nucleotide polymorphisms of their consensus motifs and cooperative binding to the ETS-CRE motif (ACCGGAAGTGACGTCA).

Project description:Previously, cooperative binding to DNA between the bZIP domain of CREB1 and the ETS domain of GABPα was observed for the composite ETS-CRE motif (A0C1C2G3G4A5A6G7T8G9A10C11G12T13C14A15). Single nucleotide polymorphisms (SNPs) at the beginning and end of the ETS motif (ACCGGAAGT) increased cooperative binding. Here, we use a microarray containing all double nucleotide polymorphisms (DNPs) of the ETS-CRE motif to explore GABPα and CREB1 binding to their canonical motifs and their cooperative binding to the ETS-CRE motif. For GABPα, binding to SNPs predicted binding the DNPs. In contrast, CREB1 binding to DNPs showed cooperativity. Similar results were observed for other ETS and bZIP family members. Cooperative binding between GABPα and CREB1 was typically weaker than expected except for DNPs containing A7 and SNPs at the beginning of the ETS motif.

2020-01-01 | GSE125613 | GEO

Microbial Product Cocktails for Personalized Cancer Immunotherapy

Project description:Microbial product cocktails induce a cytokine secretion profile in bladder cancer.

2025-06-03 | GSE298841 | GEO

Modulation of reversibility by DNA Methyltransferases during hepatogenic differentiation in Mesenchymal Stromal Cells [protein expression]

Project description:Mesenchymal stromal cells (MSCs) hold great promise in the field of liver regenerative medicine. However, the mechanisms and reversibility of hepatogenic differentiation in MSCs are poorly understood. Here, we demonstrate that hepatogenic differentiation of MSCs is a reversible process and is modulated by the transforming growth factor beta 1- DNA methyltransferases (TGF-β1-Dnmts) axis. Dnmt1 and Dnmt3a differentially regulate hepatogenic differentiation and de-differentiation in response to the alternation of TGF-β1 concentration. Knockdown of Dnmt1 accelerates the hepatogenic differentiation in MSCs-derived hepatocyte-like cells (dHeps) whereas Knockdown of Dnmt3a represses hepatogenic differentiation. Conclusions: Our finding first demonstrates that epigenetic regulation by Dnmts in response to stimulation from the surrounding microenvironment controls the reversibility of hepatogenic differentiation in MSCs. Manipulation of Dnmts provides a rapid and efficient differentiation protocol to generate functional dHeps from MSCs that may provide clinical potential for regenerative medicine.

2017-08-11 | GSE73762 | GEO

Autoantibody Profiles in Collagen Disease Patients with Interstitial Lung Disease

Project description:Auto-antibody (Ab) profiles between acute-onset diffuse ILD (AoDILD) and stable states of 25 collagen disease patients were compared to screen biomarkers or pathogenic auto-Abs.

2017-02-09 | GSE59687 | GEO

Isolation of human monoclonal antibodies from 4CMenB vaccinees reveals PorB and LOS as the main OMV components inducing cross-strain protection [ Recombinant Chip]

Project description:In this study, we describe the development and use of an ad hoc protein microarray to characterize the target of HumAbs isolated from 4CMenB vaccinated subjects and induced by the OMV component of the vaccine

2025-04-09 | GSE291739 | GEO

Isolation of human monoclonal antibodies from 4CMenB vaccinees reveals PorB and LOS as the main OMV components inducing cross-strain protection [E. coli OMV]

2025-04-09 | GSE291737 | GEO

Isolation of human monoclonal antibodies from 4CMenB vaccinees reveals PorB and LOS as the main OMV components inducing cross-strain protection [OMV MenB]

Project description:In this study, we describe the development and use of an ad hoc protein microarray to characterize the meningococccal cross-binding of HumAbs isolated from 4CMenB vaccinated subjects and induced by the OMV component of the vaccine

2025-04-09 | GSE291733 | GEO

Isolation of human monoclonal antibodies from 4CMenB vaccinees reveals PorB and LOS as the main OMV components inducing cross-strain protection [OMV Gono]

Project description:In this study, we describe the development and use of an ad hoc protein microarray to characterize the gonococcal cross-binding of HumAbs isolated from 4CMenB vaccinated subjects and induced by the OMV component of the vaccine

2025-04-09 | GSE291727 | GEO

Anti-glycan humoral responses after vaccination with PROSTVAC-VF

Project description:This SuperSeries is composed of the SubSeries listed below.

2015-08-26 | GSE50410 | GEO