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The thiosulfate sulfur transferase RDL2 contributes to the elimination of mitochondrial hydroxyl radicals in Saccharomyces cerevisiae.

ABSTRACT: Saccharomyces cerevisiae mitochondria produce more reactive sulfane sulfur than cytoplasm with unidentified enzyme. Rhodanese 2 (RDL2) maintains the stability of mitochondrial DNA in S. cerevisiae with unknown mechanism. Herein, we discovered that RDL2 was the main enzyme for reactive sulfane sulfur production in S. cerevisiae mitochondria. It decomposed thiosulfate and dialkyl polysulfide to produce hydrogen polysulfide. In vitro experiments demonstrated that the product protected plasmid DNA from hydroxyl radial-induced damage.

SUBMITTER: 王,达

PROVIDER: OEX011365 | NODE |

REPOSITORIES: NODE

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