Project description:The novel Cutibacterium modestum is a synonym of tentatively named “Cutibacterium humerusii” and often misidentified as C. acnes

| PRJEB41775 | ENA

Cutibacterium acnes strain:ATCC 6919

Project description:Cutibacterium acnes assembly complete genome

| PRJNA408272 | ENA

Hesperonemastoma modestum

Project description:Hesperonemastoma modestum Transcriptome or Gene expression

| PRJNA236521 | ENA

Cutibacterium modestum and "Propionibacterium humerusii" represent the same species that is commonly misidentified as Cutibacterium acnes.

Project description: Not available

| S-EPMC8286925 | biostudies-literature

Molecular typing and functional profiling of acne-derived Cutibacterium acnes isolates reveal determinants of skin inflammation

Project description:Cutibacterium acnes (C. acnes) is a ubiquitous skin commensal bacterium that is generally well tolerated by the immune system. Different strain-types of C. acnes have been reported to be enriched on patients with acne. To understand if these strain-types contribute to skin inflammation, we generated a library of over 200 C. acnes isolates from skin swabs of healthy and acne subjects and assessed their strain-level identity and inflammatory potential. Phylotype II K-type strains were more frequent on healthy and acne non-lesional skin compared to lesional. Phylotype IA-1 C-type strains were dominant on acne lesional skin but absent from healthy. Measurement of host cytokine responses from C. acnes supernatant revealed neither strain-type nor skin-type association predicted inflammatory potential. However, differential proinflammatory responses were induced from identical strain-types, but these differences were not attributable to protease, short chain fatty acid or porphyrin production. Instead, whole genome sequencing revealed the presence of a linear plasmid in high inflammatory strain-types. Intradermal injection of C. acnes in mouse skin revealed a plasmid-associated inflammatory response in dermal fibroblasts, revealed by single-cell RNA sequencing. We conclude that C. acnes strain-type is not sufficient to predict inflammation but other virulence factors including a plasmid may contribute to disease.

2023-08-18 | GSE211279 | GEO

Cutibacterium strain:M12

Project description:Whole genome of Cutibacterium sp. strain M12

| PRJDB8067 | ENA