Genomics

Dataset Information

235

Homo sapiens


ABSTRACT: Characterization of A Huh.7.5.1-Derived Cell Clone Highly Permissive to Hepatitis C Virus

ORGANISM(S): Homo sapiens  

PROVIDER: PRJDB2882 | ENA |

REPOSITORIES: ENA

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Publications

Robust hepatitis C virus infection in vitro.

Zhong Jin J   Gastaminza Pablo P   Cheng Guofeng G   Kapadia Sharookh S   Kato Takanobu T   Burton Dennis R DR   Wieland Stefan F SF   Uprichard Susan L SL   Wakita Takaji T   Chisari Francis V FV  

Proceedings of the National Academy of Sciences of the United States of America 20050606 26


The absence of a robust cell culture model of hepatitis C virus (HCV) infection has severely limited analysis of the HCV life cycle and the development of effective antivirals and vaccines. Here we report the establishment of a simple yet robust HCV cell culture infection system based on the HCV JFH-1 molecular clone and Huh-7-derived cell lines that allows the production of virus that can be efficiently propagated in tissue culture. This system provides a powerful tool for the analysis of host-  ...[more]

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