Dataset Information


Homo sapiens

ABSTRACT: Characterization of A Huh.7.5.1-Derived Cell Clone Highly Permissive to Hepatitis C Virus

ORGANISM(S): Homo sapiens  



altmetric image


Robust hepatitis C virus infection in vitro.

Zhong Jin J   Gastaminza Pablo P   Cheng Guofeng G   Kapadia Sharookh S   Kato Takanobu T   Burton Dennis R DR   Wieland Stefan F SF   Uprichard Susan L SL   Wakita Takaji T   Chisari Francis V FV  

Proceedings of the National Academy of Sciences of the United States of America 20050606 26

The absence of a robust cell culture model of hepatitis C virus (HCV) infection has severely limited analysis of the HCV life cycle and the development of effective antivirals and vaccines. Here we report the establishment of a simple yet robust HCV cell culture infection system based on the HCV JFH-1 molecular clone and Huh-7-derived cell lines that allows the production of virus that can be efficiently propagated in tissue culture. This system provides a powerful tool for the analysis of host-  ...[more]

Similar Datasets

| GSE29889 | GEO
2011-06-11 | E-GEOD-29889 | ArrayExpress
2008-06-27 | E-MEXP-1686 | ArrayExpress
2014-10-09 | PXD001339 | Pride
| GSE102910 | GEO
| GSE83489 | GEO
2013-06-05 | E-GEOD-41737 | ArrayExpress
| GSE68927 | GEO
2011-11-30 | E-GEOD-34022 | ArrayExpress
2015-07-30 | E-GEOD-68927 | ArrayExpress