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Mouse gut metagenome

ABSTRACT: Postnatal gut microbiota in offspring of high-fiber diet-fed mothers

PROVIDER: PRJDB9000 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	DRR198715_1.fastq.gz	Fastqsanger.gz
	DRR198715_2.fastq.gz	Fastqsanger.gz
	DRR198716_1.fastq.gz	Fastqsanger.gz
	DRR198716_2.fastq.gz	Fastqsanger.gz
	DRR198717_1.fastq.gz	Fastqsanger.gz

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mouse gut metagenome

Project description:Postnatal gut microbiota in offspring of high-fiber diet-fed mothers

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Expression data from fetal mouse lung from mothers fed high fibre or acetate

Project description:We used microarrays to detail the global programme of gene expression in the fetal lung late in gestation, from mothers that had been fed normal chow, high fibre, or acetate in the drinking water. The experiment was designed to examine the hypothesis that metabolites of the mother i.e. acetate could cross the placenta and influence gene transcription in the fetus. Diets used were "Normal chow" (NC) (8720310), or "High-fiber" (SF11-025) (Specialty feeds, Perth, Australia. Acetate (200 mM) was provided in the drinking water and refreshed three times per week. Gene expression in the lung may be affected by metabolites in utero. We examined whole lung of E21 fetuses from high-fiber fed mothers, normal chow fed mothers and acetate in drinking water fed mothers. Added fibre in the diet, or acetate in drinking water, would allow simple comparison with normal chow fed mothers, to determine whether fibre/acetate affected gene transcription in the fetal lung.

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Identification and Comparative Analyses of Myocardial miRNAs Involved in Fetal Response to Maternal Obesity

Project description:Maternal obesity programs the offspring to cardiovascular disease, insulin resistance, and obesity. We sequenced and profiled the cardiac miRNAs that were dysregulated in the hearts of baboon fetuses born to a high fat / high fructose diet fed mothers compared to a regular diet fed mothers. Fetal hearts were collected from baboon fetuses born to obese and lean mothers, total RNA was isolated, and fetal cardiac miRNA were sequenced and profiled

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Project description:Postnatal gut microbiota in offspring of FOS-supplemented mothers

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Project description:Gastrointestinal content of mice fed high or low fiber diets was labeled with the GH2c-ABP. 3x replicates of each diet, 2x littermates per diet. 12 total mice.

2022-08-11 | PXD018644 | Pride

16S rDNA sequencing of Ldlr-/- mouse gut microbiomes

Project description:We have previously demonstrated that the gut microbiota can play a role in the pathogenesis of conditions associated with exposure to environmental pollutants. It is well accepted that diets high in fermentable fibers such as inulin can beneficially modulate the gut microbiota and lessen the severity of pro-inflammatory diseases. Therefore, we aimed to test the hypothesis that hyperlipidemic mice fed a diet enriched with inulin would be protected from the pro-inflammatory toxic effects of PCB 126.

2020-02-27 | E-MTAB-8798 | biostudies-arrayexpress

Are you also what Your Mother Eats? Distinct Proteomic Portrait as a Result of Maternal High-Fat Diet in the Cerebral Cortex of the Adult Mouse.

Project description:Background: Epidemiological studies suggest an association between maternal obesity and adverse neurodevelopmental outcomes in offspring. Objective: To compare the global proteomic portrait in the cerebral cortex between mice born to mothers on a high-fat or control diet who themselves were fed a high-fat or control diet. Methods: Male mice born to dams fed a control (C) or high fat (H) diet four weeks before conception and during gestation and lactation were assigned to either C or H diet at weaning. Mice (n=24) were sacrificed at 19-weeks and their cerebral cortices were pooled into 8 samples and analysed using an iTRAQ based 2D LC-MS methodology. Results: A total of 6,695 proteins were identified and fully quantified (q<0.01). Approximately 10% of these proteins demonstrated a minimum of one Standard Deviation of regulation across all biological replicates in at least one of the experimental groups (CH, HC, HH) relative to the control (CC). Principal component analysis and hierarchical clustering analysis showed that mice clustered based on the diet of the mother and not their current diet. In silico bioinformatics analysis revealed that maternal high-fat diet was significantly associated with response to hypoxia/oxidative stress and apoptosis in the cerebral cortex of the adult offspring. Conclusion: Maternal high-fat diet was associated with distinct endophenotypic changes of the adult mouse cerebral cortex independent of the diet of the offspring. The identified modulated proteins could represent novel therapeutic targets for the prevention of neuropathological features resulting from maternal obesity.

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Maternal Western-style diet alters the transcriptome of chemically induced mammary tumors in female offspring rats

Project description:Some previous experimental studies have shown that early in life intake of high-fat or Western-style diets did alter the development of mammary cancer in adulthood female rats. Thus, the present study investigated the distinct gene expression patterns of chemically induced mammary tumors derived from female offspring whose dams intake control diet (CD) or Western-style diet (WD). During gestational days (GD) 12-21 and post-natal days (PND) 1-21, pregnant Sprague-Dawley (SD) rats were fed a CD diet or WD (high-fat and low-fiber and oligoelements) diet. On postnatal day (PND) 21, the female offspring received a single dose of carcinogen N-Methyl-N-Nitrosourea (MNU, 50 mg/kg) and CD diet for 12 weeks. Latency, incidence and tumor burden were registered. Mammary tumors samples were collected and histopathology and gene expression analysis were performed.

2018-10-12 | GSE96520 | GEO

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