Dataset Information


Polymerase Error Rates by PacBio Sequencing

ABSTRACT: Polymerase Specific Error Rates and Profiles Identified by PacBio Single Molecule Sequencing



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Polymerase specific error rates and profiles identified by single molecule sequencing.

Hestand Matthew S MS   Van Houdt Jeroen J   Cristofoli Francesca F   Vermeesch Joris R JR  

Mutation research 20160119

DNA polymerases have an innate error rate which is polymerase and DNA context specific. Historically the mutational rate and profiles have been measured using a variety of methods, each with their own technical limitations. Here we used the unique properties of single molecule sequencing to evaluate the mutational rate and profiles of six DNA polymerases at the sequence level. In addition to accurately determining mutations in double strands, single molecule sequencing also captures direction sp  ...[more]

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