Project description:This study is aimed: 1) to compare the accuracy of colonoscopy vs immunochemical faecal occult blood test (iFOBT) and colonoscopy when positive for colorectal cancer (CRC) screening in familiar-risk population and; 2) to determine the complications associated with both strategies.
Project description:Study hypothesis: Implementation of colorectal cancer screening with Faecal Occult Blood Test (FOBT) in the Netherlands is feasible.
Please note that the follow-up study to this randomised controlled trial can be found at ISRCTN94861265: Screening Or NO Screening: differences in survival during follow-up after random colorectal cancer screening with faecal occult blood test or no screening.
Primary outcome(s): Response rate per FOBT, measured at T2.
Project description:The main purpose of the study is to compare the acceptance and viability of three strategies aimed to screen hepatitis C virus (HCV) infection in a birth cohort by: a) invitation letter offering HCV screening with dried blood spot (DBS) testing at the primary care center, b) invitation letter offering both HCV and colorectal cancer (CCR) screening with faecal occult test (FOT) at the primary care center, and c) invitation letter offering self-collected screening at home for HCV and CCR.
Project description:The aim of this study is to compare the outcome of three (3) quantitative immunochemical faecal occult blood test in symptomatic patients.
Project description:Interventions: Ongoing annual offer of faecal occult blood test screening in years when colonoscopy not scheduled, within a colonoscopy based surveillance program. At present the duration would be ongoing till the invitee reaches 75 years, then subject to invitee’s wishes and health status.
Primary outcome(s): Program yield of neoplasia.[7 years from initiation of program.]
Study Design: Purpose: Prevention; Allocation: Non-randomised trial; Masking: Open (masking not used);Assignment: Parallel;Type of endpoint: Efficacy
Project description:Study hypothesis: Survival after screening for colorectal cancer with faecal occult blood test is increased compared with no screening.
Please note that this is the follow-up trial to ISRCTN57917442: Implementation of colorectal cancer screening with Faecal Occult Blood Test (FOBT) in the Netherlands.
Primary outcome(s): Survival
In each year of the follow-up (timepoints T9 - T11), the population will be censored for:
1. Mortality of colorectal cancer
2. Mortality of other causes
3. Other reasons for loss to follow-up
Project description:RNAseq and LC/MS metabolomics analysis of C. difficile strain 630 grown in BHIS media with 50% (vol/vol) faecal water added, compared with control BHIS containing only the additional PBS used for prep of Faecal water. Cells grown in biological triplicates to late log phase (T=6h) prior to harvest. Goal was to determine changes in gene expression caused by exposure to Faecal water, and changes in the metabolite profile of faecal water containing medium when incubated with actively growing C. difficile cells
