Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Salmonella enterica serovar Bovismorbificans genomics

ABSTRACT: Genomic Characterisation of Invasive Non-Typhoidal Salmonella enterica Subspecies enterica Serovar Bovismorbificans Isolates from Malawi

PROVIDER: PRJEB1776 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Comparative analysis of Salmonella Typhi, Paratyphi A, Enteritidis and Typhimurium core proteomes

Project description:Salmonella enterica subsp. enterica contains more than 2,600 serovars of which four are of major medical relevance for humans. While the typhoidal serovars (Typhi and Paratyphi A) are human-restricted and cause enteric fever, non-typhoidal Salmonella serovars (Typhimurium and Enteritidis) have a broad host range and predominantly cause gastroenteritis. In this study, we compared the core proteomes of Salmonella Typhi, Paratyphi A, Typhimurium and Enteritidis using contemporary proteomics. Five isolates, covering different geographical origins, and one reference strain per serovar were grown in vitro to the exponential phase. Protein levels of orthologous proteins between serovars were compared and subjected to gene ontology term enrichment and inferred regulatory interactions. Differential expression of the core proteomes of the typhoidal serovars appears mainly related to cell surface components and, for the non-typhoidal serovars, to pathogenicity. Our findings may guide future development of novel diagnostics and vaccines, and understanding of disease progression.

2019-05-13 | PXD011154 | Pride

Salmonella enterica subsp. enterica serovar Bovismorbificans

Project description:Salmonella enterica subsp. enterica serovar Bovismorbificans Genome sequencing and assembly

| PRJNA230004 | ENA

Typhoidal Salmonella Dendritic Cell Survival Mechanism Revealed by Dual RNA sequencing

Project description:Salmonella enterica represent a major disease burden worldwide. While non-typhoidal Salmonella (NTS) serovars trigger self-limiting diarrhoea, leading to occasional secondary bacteraemia, S. enterica serovar Typhi is responsible for potentially life-threatening Typhoid fever. Dendritic cells (DCs) are key professional antigen presenting cells of the human immune system. The ability of pathogenic bacteria to subvert DC functions and prevent T cell recognition contributes to their survival and dissemination within the host. Here, we adapted Dual RNA-sequencing to define how different Salmonella pathovariants remodel their gene expression in tandem with that of infected DCs. We find DCs harness iron handling pathways to defend against invading Salmonellas, which, the human pathogen S. Typhi is able to circumvent. We show that S. Typhi mounts a robust response to host oxidative stress to avoid host iron-mediated defence mechanisms. In parallel, we provide evidence that invasive non-typhoidal Salmonella employs several strategies to impair DC functions and undertake alternative nutrient scavenging strategies to survive in the hostile intracellular environment.

2021-11-17 | GSE161854 | GEO

Salmonella enterica subsp. enterica serovar Bovismorbificans isolate:food

Project description:Salmonella enterica subsp. enterica serovar Bovismorbificans isolate:food Genome sequencing

| PRJNA722181 | ENA

Translation landscape of the enteric pathogen Salmonella enterica serova Typhimurium

Project description:Many non-typhoidal serovars of Salmonella such as Salmonella enterica serovar Typhimurium (S. Typhimurium) are the leading cause of food-borne gastroenteritis, resulting in millions of infections each year and sometimes death. Salmonella enterica serovar Typhimurium is the most common non-typhoidal Salmonella strain isolated from patients around the world and is used as a mouse model to study bacterial pathogenesis and host-microbe interactions. Furthermore, S. Typhimurium is an important pathogen in livestock animals including chickens and cattle. S. Typhimurium utilises a multitude of virulence factors to reach and invade host cells and for its intracellular survival. However, little is known about the mechanism of protein synthesis of these virulence factors at the codon level. Here, we performed RNA-seq and ribosome profiling. Ribosome profiling allows the global mapping of translating ribosomes on the transcriptome and therefore provides direct measure of protein synthesis.

2023-04-01 | E-MTAB-8808 | biostudies-arrayexpress

Salmonella enterica subsp. enterica serovar Bovismorbificans strain:1588

Project description:Salmonella enterica subsp. enterica serovar Bovismorbificans strain:1588 Genome sequencing and assembly

| PRJNA576819 | ENA

Salmonella enterica subsp. enterica serovar Bovismorbificans strain:41

Project description:Salmonella enterica subsp. enterica serovar Bovismorbificans strain:41 Genome sequencing and assembly

| PRJNA615056 | ENA

Salmonella enterica subsp. enterica serovar Bovismorbificans strain:2449

Project description:Salmonella enterica subsp. enterica serovar Bovismorbificans strain:2449 Genome sequencing and assembly

| PRJNA615079 | ENA

Salmonella enterica subsp. enterica serovar Bovismorbificans strain:2557

Project description:Salmonella enterica subsp. enterica serovar Bovismorbificans strain:2557 Genome sequencing and assembly

| PRJNA615083 | ENA

Salmonella enterica subsp. enterica serovar Bovismorbificans strain:2605

Project description:Salmonella enterica subsp. enterica serovar Bovismorbificans strain:2605 Genome sequencing and assembly

| PRJNA615086 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data