Genomics

Dataset Information

299


ABSTRACT: Antibody heavy chain variable domains encoded in transcriptomes of bone marrow and peripheral blood of allergic subjects.

PROVIDER: PRJEB18926 | ENA |

REPOSITORIES: ENA

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Publications

Parallel antibody germline gene and haplotype analyses support the validity of immunoglobulin germline gene inference and discovery.

Kirik Ufuk U   Greiff Lennart L   Levander Fredrik F   Ohlin Mats M  

Molecular immunology 20170404


Analysis of antibody repertoire development and specific antibody responses important for e.g. autoimmune conditions, allergy, and protection against disease is supported by high throughput sequencing and associated bioinformatics pipelines that describe the diversity of the encoded antibody variable domains. Proper assignment of sequences to germline genes are important for many such processes, for instance in the analysis of somatic hypermutation. Germline gene inference from antibody-encoding  ...[more]

Publication: 1/3

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