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Added diagnostic value of sonication of heart valves in infective endocarditis, a case-control study

ABSTRACT: Added diagnostic value of sonication of heart valves in infective endocarditis, a case-control study

PROVIDER: PRJEB20613 | ENA |

REPOSITORIES: ENA

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Transcription profiling of cardiac valves from patients with bacterial infectious endocarditis

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2009-10-23 | E-MEXP-1334 | biostudies-arrayexpress

Identification of host endotypes using peripheral blood transcriptomics in a prospective cohort of patients with endocarditis [pre]

Project description:Infective endocarditis is a severe disease caused by the infection of heart valves and endocardium by pathogenic germ. Antimicrobial therapy and surgery remain the basis of treatment, and up to 50% of the patients require surgical replacement of the affected valves to control the infectious source. The objective of this work is to identify the existence of endotypes in a prospective cohort of patients with infective endocarditis. We performed a bulk RNA-seq form peripheral blood to cluster patients according to their transcriptomic profiles at diagnosis and during their follow-up. Clinical data, outcomes and response to surgery were assessed in a cluster-specific manner, in order to identify differences in the pathogenesis that could help to find personalized treatments and improve the outcome.

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Identification of host endotypes using peripheral blood transcriptomics in a prospective cohort of patients with endocarditis [pre-post_qx]

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Dataset in support of patients on clinical suspicion of infective endocarditis included in a study searching for novel putative biomarkers

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Project description:Infective endocarditis results in the growth of a vegetative mass on native or bio prosthetic valves hindering function and increasing risk of thromboses. This study set out to determine the proteomic composition of these vegetations including the influence of different micro-organisms and the proteases known to be present. Our data has allowed us to describe for first time the influence different infectious organisms have on vegetation growth. Including the contribution of the immune response and circulatory proteins/cells make in composing a vegetation. Furthermore, we describe the protease activity and both known and novel cleavage sites in a plethora of targets. This data provides a deep insight into the homogeneity and heterogeneity of vegetation composition.

2020-07-29 | PXD019129 | Pride

Protein components of infective endocarditis vegetations and insights on their proteolysis using mass spectrometry-based N-terminomics

Project description:Infective endocarditis results in the growth of a vegetative mass on native or bio prosthetic valves hindering function and increasing risk of thromboses. This study set out to determine the proteomic composition of these vegetations including the influence of different micro-organisms and the proteases known to be present. Our data has allowed us to describe for first time the influence different infectious organisms have on vegetation growth. Including the contribution the immune response and circulatory proteins/cells make in composing a vegetation. Furthermore, we describe the protease activity and both known and novel cleavage sites in a plethora of targets. This data provides a deep insight into the homogeneity and heterogeneity of vegetation composition.

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Staphylococcus aureus gene expression in a rat model of infective endocarditis

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