Genomics

Dataset Information

0

Gut mictobiota composition correlation with the clinical outcome of NSCLC and RCC patients treated with anti-PD-1 mAB


ABSTRACT: Gut mictobiota composition correlation with the clinical outcome of NSCLC and RCC patients treated with anti-PD-1 mAB

PROVIDER: PRJEB22863 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
ERR2213660.fastq.gz Fastqsanger.gz
ERR2213670.fastq.gz Fastqsanger.gz
ERR2213680.fastq.gz Fastqsanger.gz
ERR2213690.fastq.gz Fastqsanger.gz
ERR2213700.fastq.gz Fastqsanger.gz
Items per page:
1 - 5 of 219
altmetric image

Publications

Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors.

Routy Bertrand B   Le Chatelier Emmanuelle E   Derosa Lisa L   Duong Connie P M CPM   Alou Maryam Tidjani MT   Daillère Romain R   Fluckiger Aurélie A   Messaoudene Meriem M   Rauber Conrad C   Roberti Maria P MP   Fidelle Marine M   Flament Caroline C   Poirier-Colame Vichnou V   Opolon Paule P   Klein Christophe C   Iribarren Kristina K   Mondragón Laura L   Jacquelot Nicolas N   Qu Bo B   Ferrere Gladys G   Clémenson Céline C   Mezquita Laura L   Masip Jordi Remon JR   Naltet Charles C   Brosseau Solenn S   Kaderbhai Coureche C   Richard Corentin C   Rizvi Hira H   Levenez Florence F   Galleron Nathalie N   Quinquis Benoit B   Pons Nicolas N   Ryffel Bernhard B   Minard-Colin Véronique V   Gonin Patrick P   Soria Jean-Charles JC   Deutsch Eric E   Loriot Yohann Y   Ghiringhelli François F   Zalcman Gérard G   Goldwasser François F   Escudier Bernard B   Hellmann Matthew D MD   Eggermont Alexander A   Raoult Didier D   Albiges Laurence L   Kroemer Guido G   Zitvogel Laurence L  

Science (New York, N.Y.) 20171102 6371


Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis induce sustained clinical responses in a sizable minority of cancer patients. We found that primary resistance to ICIs can be attributed to abnormal gut microbiome composition. Antibiotics inhibited the clinical benefit of ICIs in patients with advanced cancer. Fecal microbiota transplantation (FMT) from cancer patients who responded to ICIs into germ-free or antibiotic-treated mice ameliorated the antitumor effects of PD-1 blocka  ...[more]

Similar Datasets

2019-01-01 | S-EPMC6653643 | BioStudies
2011-01-01 | S-EPMC3065286 | BioStudies
2018-01-01 | S-EPMC6354674 | BioStudies
2019-01-01 | S-EPMC6771773 | BioStudies
| S-EPMC2849899 | BioStudies
| S-EPMC4370182 | BioStudies
1000-01-01 | S-EPMC5844731 | BioStudies
| S-DIXA-D-1045 | BioStudies
2014-01-21 | E-GEOD-40913 | BioStudies
2012-01-01 | S-EPMC3383016 | BioStudies