Genomics

Dataset Information

599

Streptococcus pneumoniae evolution and population structure during longitudinal sampling in a defined human population


ABSTRACT: Streptococcus pneumoniae evolution and population structure during longitudinal sampling in a defined human population

PROVIDER: PRJEB2479 | ENA |

REPOSITORIES: ENA

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Evasion of clinical interventions by Streptococcus pneumoniae occurs through selection of non-susceptible genomic variants. We report whole-genome sequencing of 3,085 pneumococcal carriage isolates from a 2.4-km(2) refugee camp. This sequencing provides unprecedented resolution of the process of recombination and its impact on population evolution. Genomic recombination hotspots show remarkable consistency between lineages, indicating common selective pressures acting at certain loci, particular  ...[more]

Publication: 1/2

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