Genomics

Dataset Information

294

Non-random mis-segregations of human chromosomes following induction of merotelic attachments.


ABSTRACT: Single-cell whole genome sequencing data to determine chromosome mis-segregation events

PROVIDER: PRJEB25738 | ENA |

REPOSITORIES: ENA

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Publications


A common assumption is that human chromosomes carry equal chances of mis-segregation during compromised cell division. Human chromosomes vary in multiple parameters that might generate bias, but technological limitations have precluded a comprehensive analysis of chromosome-specific aneuploidy. Here, by imaging specific centromeres coupled with high-throughput single-cell analysis as well as single-cell sequencing, we show that aneuploidy occurs non-randomly following common treatments to elevat  ...[more]

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