Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Origin and consequences of chromosomal inversions in the virilis group of Drosophila

ABSTRACT: Origin and consequences of chromosomal inversions in the virilis group of Drosophila

PROVIDER: PRJEB27094 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Origin and Consequences of Chromosomal Inversions in the virilis Group of Drosophila.

Project description: Not available

| S-EPMC6278893 | biostudies-literature

Evaluation of the impact of chromosomal inversions on replication origin usage in fission yeast

Project description:Eukaryotic DNA replication is regulated by conserved mechanisms that bring about a spatial and temporal organization in which distinct genomic domains are copied at characteristic times during S phase. Although this replication program has been closely linked with genome architecture, we still do not understand key aspects of how chromosomal context modulates the activity of replication origins. To address this question, we have exploited models that combine engineered genomic rearrangements with the unique replication programs of post-quiescence and pre-meiotic S phases. Our results demonstrate that large-scale inversions surprisingly do not affect cell proliferation and meiotic progression, despite inducing a restructuring of replication domains on each rearranged chromosome. Remarkably, these alterations in the organization of DNA replication are entirely due to changes in the positions of existing origins along the chromosome, as their efficiencies remain virtually unaffected genome wide. However, we identified striking alterations in origin firing proximal to the fusion points of each inversion, suggesting that the immediate chromosomal neighborhood of an origin is a crucial determinant of its activity. Interestingly, the impact of genome reorganization on replication initiation is highly comparable in the post-quiescent and pre-meiotic S phases, despite the differences in DNA metabolism in these two physiological states. Our findings therefore shed new light on how origin selection and the replication program are governed by chromosomal architecture. Genes 2022, 13(7), 1244; https://doi.org/10.3390/genes13071244

2022-08-12 | GSE210821 | GEO

Chromosomal origin utilisation in Haloferax meiditerranei wild type and mutant strains

2015-07-08 | GSE70597 | GEO

Drosophila virilis

Project description:Drosophila virilis Genome sequencing

| PRJNA242283 | ENA

RNA profiling in Drosophila virilis and Drosophila yakuba

Project description:Gene annoation and determination of gene expression levels in Drosophila virilis and Drosophila yakuba by deep sequencing.

2015-01-29 | GSE61222 | GEO

Chromosomal origin utilisation in Haloferax meiditerranei wild type and mutant strains

Project description:We have comprehensively explored the origin utilisation in Haloferax mediterranei. Here we report three active chromosomal origins by genome-wide replication profiling, and demonstrate that when these three origins are deleted, a dormant origin becomes activated. Genomic DNA was extracted from the H. mediterranei cultures at specific time points(12h,18h,24h,36h,42h and stationary phase 66h), or during the exponential phase (OD600≈0.5) and stationary phase (OD600≈4.0)for the origin deletion strains. After being lablled, Genomic DNA from exponential phase and stationary phase were hybridized to Haloferax mediterranei genome array genechips.

2015-07-08 | E-GEOD-70597 | biostudies-arrayexpress

Small RNA expression throughout the development of Drosophila virilis

Project description:Examination of temporal small RNA expression during the embryonic development, larval and adult stages of Drosophila virilis

2014-01-13 | GSE54009 | GEO

On the Origin and Evolutionary Consequences of Gene Body DNA Methylation

Project description:On the Origin and Evolutionary Consequences of Gene Body DNA Methylation

| PRJNA302602 | ENA

Drosophila virilis

Project description:Drosophila virilis Raw sequence reads

| PRJNA413683 | ENA

RNA profiling in Drosophila virilis and Drosophila yakuba

Project description:Gene annoation and determination of gene expression levels in Drosophila virilis and Drosophila yakuba by deep sequencing. Total RNA-seq data from heads of 2-5 day old mated D virilis and D yakuba females, 1 sample from each species.

2015-01-29 | E-GEOD-61222 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data