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RNAseq of enterocytes of the jejunum and Ileum from transgene C57BL/6 mice harboring a CKIαΔgut knock-out

ABSTRACT: RNAseq of enterocytes of the jejunum and Ileum from transgene C57BL/6 mice harboring a CKIαΔgut knock-out

PROVIDER: PRJEB32071 | ENA |

REPOSITORIES: ENA

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RNAseq of enterocytes of the jejunum and Ileum from transgene C57BL/6 mice harboring a CKIαΔgut knock-out

Project description:RNAseq of enterocytes of the jejunum and Ileum from transgene C57BL/6 mice to assess the effects of a CKIα knock-out in combination with expression of a p53 mutant protein (R172H ) compared to a double knock-out of CKIα and p53. In addition, a group of mice exhibiting a CKIα knock-out and mutant p53 (R172H) was treated with gallic acid and compared to untreated mice (Jejunum only).

2020-02-25 | E-MTAB-7859 | biostudies-arrayexpress

ChIPseq of enterocytes of the jejunum from transgene C57BL/6 mice harboring a CKIαΔgut knock-out

Project description:ChIPseq of enterocytes of the jejunum from transgene C57BL/6 mice to assess the effects of a CKIαΔgut knock-out in the jejunum and a CKIαΔgut/p53 double knock-out. In addition, enterocytes expressing a mutant p53 (R172H) in combination with CKIαΔgut knockout were analyzed.

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ChIPseq of enterocytes of the jejunum from transgene C57BL/6 mice harboring a CKIαΔgut knock-out

Project description:ChIPseq of enterocytes of the jejunum from transgene C57BL/6 mice harboring a CKIαΔgut knock-out

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Gene expression profile of ileum, jejunum and colon

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Project description:Results of RNA-seq of normal C57BL/6 small intestinal epithelial cells sorted from duodenum, jejunum and ileum separately. Samples are named as follow; mouse replicate number-duodenum(1), jejunum(2) or ileum(3). For example, 1-1, 1-2 and 1-3 representing duodenum, jejunum and ileum respectively from mouse replicate number 1.

2021-01-21 | E-MTAB-9744 | biostudies-arrayexpress

E-MTAB-7859

Project description:RNAseq of enterocytes of the jejunum and Ileum from transgene C57BL/6 mice harboring a CKIαΔgut knock-out

2019-09-09 | E-MTAB-7859 | ExpressionAtlas

Region-specific identity of small intestinal stem cells from the ileum and jejunum

Project description:We report the expression profiles of three stem-cell varieties derived from the ileum and jejunum, focusing on gene signatures that are consistent in all stem cells of an intestinal location. We find that intestinal stem cells establish and maintain a regional identity that is discernable through gene expression patterns consistent with intestinal function particular to that region.

2015-07-01 | GSE53545 | GEO

Gene expression profile of ileum, jejunum and colon

Project description:Gene expression profile of ileum, jejunum and colon

| PRJNA600172 | ENA

Project description:Rationale: Sepsis is a multi-organ disease affecting the ileum and jejunum (small intestine),liver, skeletal muscle, and lung clinically. Recently, specific alterations in circulating metabolites have been found in patients with sepsis which are thought to contribute to the pathogenesis of disease. The specific metabolic changes in the ileum, jejunum, liver, skeletal muscle, and lung have not previously been investigated. Methods: Live Pseudomonas aeruginosa isolated from a patient was given via IV catheter to pigs to induce severe sepsis. Eighteen hours later, ileum, jejunum, medial gastrocnemius skeletal muscle, liver, and lung were harvested and flash frozen. Tissues were subsequently processed for non-targeted metabolomics analysis using gas chromatography/mass spectrometry. Results: After 18 hours of sepsis, the ileum and the liver demonstrated significant changes in metabolites involved in linoleic acid metabolism, the ileum and lung had significant changes in valine/leucine/isoleucine metabolism, the jejunum, skeletal muscle, and liver had significant changes in arginine/ proline metabolism, and the skeletal muscle and lung had significant changes in aminoacyl-tRNA biosynthesis by pathway analysis. Pathway analysis also identified changes in metabolic pathways unique for different tissues, including changes in the citric acid cycle (jejunum), beta-alanine metabolism (skeletal muscle), and purine metabolism (liver). Conclusion: These findings demonstrate both overlapping metabolic pathways affected in different tissues and those that are unique to others and provide insight into the metabolic changes in sepsis leading to organ dysfunction. This may allow therapeutic interventions that focus on multiple tissues or single tissues once the relationship of the altered metabolites/metabolism to the underlying pathogenesis of sepsis is determined.

2018-12-03 | ST001190 | MetabolomicsWorkbench

Transcription profiling of human intestinal cells (Caco-2) and tissues from all intestinal segments (duodenum, jejunum, ileum, colon)

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