Project description:Influenza virus transmission between mothers and nursing-infants has not been investigated although mothers and infants often develop severe disease. Ferrets are considered the most appropriate model for influenza studies. We investigated influenza transmission in infant and nursing-mother ferrets. Influenza infected infants transmitted virus to mother mammary glands leading to live virus excretion in milk and influenza virus positive mammary gland epithelial cells. Global gene expression analysis showed down-regulation of milk production and induction of breast involution and oncogenesis pathways. Our results provide insight into influenza transmission between mothers and infants which may impact fields of infectious disease, maternal/infant health and neoplasm etiology. Total RNA was obtained from nursing mother ferret mammary glands at days 3/4 and 6/7 post-intranasal kit infection with 10^5 EID50 A/California/07/2009 (H1N1). Total RNA was also collected from uninfected control nursing mother mammary gland tissues (n = 3). Changes in gene expression relative to uninfected tissue controls were then investigated.

2015-09-10 | E-GEOD-63082 | biostudies-arrayexpress

The human milk proteome: exploring associations with allergy of mother and child

Project description:The aim of this study was to investigate how the human milk proteome relates to allergy of the mother and allergy development in the infant.

2022-10-31 | PXD034806 | Pride

Breastfeeding infants transmit influenza virus to the mammary glands during feeding [Dataset Part II]

2015-09-10 | GSE63083 | GEO

Breastfeeding infants transmit influenza virus to the mammary glands during feeding [Dataset Part I]

2015-09-10 | GSE63082 | GEO

human gut metagenome

Project description:Evaluation of vertical transmission between mother-infant

| PRJNA287207 | ENA

Breastfeeding infants transmit influenza virus to the mammary glands during feeding [Dataset Part II]

Project description:Influenza virus transmission between mothers and nursing-infants has not been investigated although mothers and infants often develop severe disease. Ferrets are considered the most appropriate model for influenza studies. We investigated influenza transmission in infant and nursing-mother ferrets. Influenza infected infants transmitted virus to mother mammary glands leading to live virus excretion in milk and influenza virus positive mammary gland epithelial cells. Global gene expression analysis showed down-regulation of milk production and induction of breast involution and oncogenesis pathways. Our results provide insight into influenza transmission between mothers and infants which may impact fields of infectious disease, maternal/infant health and neoplasm etiology. Total RNA was obtained from ferret lungs at days 3 and 6 post-intranasal infection with 10^5 EID50 A/California/07/2009 (H1N1) (n = 3/time-point). Total RNA was also collected from uninfected control lung tissues (n = 3). Changes in gene expression relative to uninfected tissue controls were then investigated.

2015-09-10 | E-GEOD-63083 | biostudies-arrayexpress

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