Project description:Exploring non-genetic evolution of cell states during cancer treatments has become attainable by recent advances in lineage-tracing methods. However, transcriptional changes that drive cells into resistant fates may be subtle, necessitating high resolution analysis. We developed ReSisTrace that uses shared transcriptomic features of synchronized sister cells to predict the states that prime treatment resistance. We applied ReSisTrace in ovarian cancer cells to dissect primed resistance against olaparib, carboplatin or natural killer (NK) cells, and discovered a novel connection between DNA repair deficiency and susceptibility to NK cells. Furthermore, we identified small molecules driving cells to sensitive states prior to treatment. In summary, ReSisTrace resolves pre-existing transcriptional features of treatment vulnerability, facilitating both molecular patient stratification for personalized treatments and discovery of synergistic pre-sensitizing therapies.

2023-12-22 | GSE223003 | GEO

Tracing the first steps of American sturgeon pioneers in Europe.

Project description: Not available

| S-EPMC2527320 | biostudies-literature

Morphological divergence in giant fossil dormice.

Project description: Not available

| S-EPMC7735280 | biostudies-literature

Ecosystem size predicts eco-morphological variability in a postglacial diversification.

Project description: Not available

| S-EPMC5552947 | biostudies-literature

Hunger-Driven Motivational State Competition.

Project description: Not available

| S-EPMC5082717 | biostudies-literature

Eco-morphological differentiation in Lake Magadi tilapia

Project description:Eco-morphological differentiation in Lake Magadi tilapia, an extremophile cichlid fish living in hot, alkaline and hypersaline lakes in East Africa

| PRJEB11365 | ENA

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