Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Xanthomonas euroxanthea CPBF 424 hybrid assembly

ABSTRACT: Xanthomonas euroxanthea CPBF 424 complete genome assembly

PROVIDER: PRJEB42194 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

TWIST1-induced microRNA-424 drives an intermediate epithelial-to-mesenchymal transition that opposes metastasis

Project description:Epithelial-to-mesenchymal transition (EMT) is a dynamic process that relies on cellular plasticity; an EMT/MET axis is critical for metastatic colonization of carcinomas. Unlike epithelial programming, regulation of mesenchymal programming is not well understood in EMT. Here we describe the first microRNA that enhances exclusively mesenchymal programming. We demonstrate that microRNA-424 is up-regulated early during a TWIST1/SNAI1-induced EMT, and that it causes cells to express mesenchymal genes without affecting epithelial genes, resulting in a mixed/intermediate EMT. Further, microRNA-424 increases motility, decreases adhesion and induces a growth arrest, changes associated with a complete EMT. Patient microRNA-424 levels positively associate with TWIST1/2 and EMT-like gene signatures and is increased in primary tumors versus matched normal breast. However, microRNA-424 is down-regulated in metastases versus matched primary tumors. Correspondingly, microRNA-424 decreases tumor initiation and is post-transcriptionally down-regulated in macrometastases in mice. RNA-seq identified microRNA-424 regulates numerous genes associated with EMT and breast cancer stemness including the novel miR-424 target, TGFBR3, which regulates mesenchymal phenotypes without influencing miR-424 effects on tumor-initiating phenotypes; instead, we show that ERK signaling is critical for such tumor-initiating effects of miR-424. These findings suggest microRNA-424 plays distinct roles downstream of EMT-inducing factors, facilitating earlier stages, but repressing later stages, of metastasis. Examination of mRNA levels in MCF12A human breast cell lines that stably over-expressed miR-424 or an empty vector (EV) control. Each group has three replicates.

2015-02-26 | E-GEOD-54505 | biostudies-arrayexpress

TWIST1-induced microRNA-424 drives an intermediate epithelial-to-mesenchymal transition that opposes metastasis

2015-02-26 | GSE54505 | GEO

Pseudomonas sp. 424

Project description:Pseudomonas sp. 424 Genome sequencing

| PRJNA439514 | ENA

Tulasnella sp. 424

Project description:Tulasnella sp. 424 Resequencing genome sequencing

| PRJNA557747 | ENA

Bradyrhizobium centrosematis strain:SEMIA 424 | isolate:SEMIA 424

Project description:Bradyrhizobium centrosematis SEMIA 424 genome sequencing

| PRJNA581047 | ENA

Ureibacillus acetophenoni strain:424

Project description:Ureibacillus acetophenoni strain:424

| PRJNA684019 | ENA

Transcriptional profiling of sweet orange leaves infected with Xanthomonas citri and Xanthomonas aurantifolii pathotype C

Project description:To compare the early transcriptional changes that occur in sweet orange leaves in response to Xanthomonas citri versus Xanthomonas aurantifolii pathotype C infection, plant leaves infiltrated with each bacterial pathogen were examined by RNAseq.

2022-05-11 | GSE202469 | GEO

Transcriptome Profiling of Xanthomonas oryzae pv. oryzae and Xanthomonas oryzae pv. oryzicola

Project description:This SuperSeries is composed of the following subset Series: GSE9640: Transcriptome Profiling of Xanthomonas oryzae pv. oryzae and Xanthomonas oryzae pv. oryzicola on two different medias GSE9643: Transcriptome Profiling of Xanthomonas oryzae pv. oryzae knockout mutants at different hybridization conditions and PMTs Keywords: SuperSeries Refer to individual Series

2010-05-26 | E-GEOD-9658 | biostudies-arrayexpress

Firmicutes bacterium CAG:424

Project description:Firmicutes bacterium CAG:424 overview

| PRJNA207233 | ENA

Sphingomonas sp. PP-CE-1G-424

Project description:Sphingomonas sp. PP-CE-1G-424 Genome sequencing and assembly

| PRJNA443282 | ENA