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Lineage recording in human cerebral organoids (iTracer-perturb)

ABSTRACT: Lineage recording in human cerebral organoids (iTracer-perturb)

PROVIDER: PRJEB47708 | ENA |

REPOSITORIES: ENA

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Lineage recording in human cerebral organoids (iTracer-perturb)

Project description:Induced pluripotent stem cell (iPSC) derived organoid systems provide models to study human organ development. Single-cell transcriptome sequencing enables highly-resolved descriptions of cell state heterogeneity within these systems and computational methods can reconstruct developmental trajectories. However, new approaches are needed to directly measure lineage relationships in these systems. Here we establish an inducible dual channel lineage recorder, iTracer, that couples reporter barcodes, inducible CRISPR/Cas9 scarring, and single-cell transcriptomics to analyze state and lineage relationships in iPSC-derived systems. This data set include the iTracer-perturb data of one cerebral organoid with simultaneous TSC2 perturbation and lineage recording.

2021-11-03 | E-MTAB-10971 | biostudies-arrayexpress

Lineage recording in human cerebral organoids (whole organoids)

Project description:Lineage recording in human cerebral organoids (whole organoids)

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Lineage recording in human cerebral organoids (Visium)

Project description:Lineage recording in human cerebral organoids (Visium)

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Lineage recording in human cerebral organoids (microdissected)

Project description:Lineage recording in human cerebral organoids (microdissected)

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Lineage recording in human cerebral organoids (whole organoids)

2021-11-03 | E-MTAB-10974 | biostudies-arrayexpress

Lineage recording in human cerebral organoids (Visium)

Project description:Induced pluripotent stem cell (iPSC) derived organoid systems provide models to study human organ development. Single-cell transcriptome sequencing enables highly-resolved descriptions of cell state heterogeneity within these systems and computational methods can reconstruct developmental trajectories. However, new approaches are needed to directly measure lineage relationships in these systems. Here we establish an inducible dual channel lineage recorder, iTracer, that couples reporter barcodes, inducible CRISPR/Cas9 scarring, and single-cell transcriptomics to analyze state and lineage relationships in iPSC-derived systems. This data set include the spatial iTracer data of three slices of one cerebral organoid measured by 10x Visium.

2021-11-03 | E-MTAB-10972 | biostudies-arrayexpress

Lineage recording in human cerebral organoids (microdissected)

Project description:Induced pluripotent stem cell (iPSC) derived organoid systems provide models to study human organ development. Single-cell transcriptome sequencing enables highly-resolved descriptions of cell state heterogeneity within these systems and computational methods can reconstruct developmental trajectories. However, new approaches are needed to directly measure lineage relationships in these systems. Here we establish an inducible dual channel lineage recorder, iTracer, that couples reporter barcodes, inducible CRISPR/Cas9 scarring, and single-cell transcriptomics to analyze state and lineage relationships in iPSC-derived systems. This data set include the iTracer data of two microdissected regions of one cerebral organoid.

2021-11-03 | E-MTAB-10973 | biostudies-arrayexpress

Lineage recording in human cerebral organoids.

Project description: Not available

| S-EPMC8748197 | biostudies-literature

Bulk ATAC-seq of primate cerebral organoids

Project description:Bulk ATAC-seq was performed on human, chimpanzee, bonobo, and macaque stem cell-derived cerebral organoids. ATAC-seq was performed on day 60 (2 months old) and day 120 (4 months old) cerebral organoids.

2019-10-16 | E-MTAB-8228 | biostudies-arrayexpress

Cerebral organoids proteomics - Human Cerebral Organoids and Fetal Brain Tissue Share Proteomic Similarities

Project description:Pluripotent stem cells (PSC) can differentiate inot any cell type of an organism. Their remarkable capability of self-organization enables the formation of three-dimensional structures that resembles miniature organs, including cerebral organoids. These organoids can recreate early steps of the human cerebral cortex development, and show great potential for modeling human diseases, particularly for those with a developmental component. This data evidences stem cell-derived cerebral organoids as a key model to study brain development and neurodevelopmental, neurodegenerative and neuropsychiatric diseases.

2019-11-15 | PXD011605 | Pride

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