Genomics

Dataset Information

294

Fecal Microbiome in Parkinson's Disease


ABSTRACT: Alterations of the Fecal Microbiome in Parkinson's Disease

PROVIDER: PRJEB4927 | ENA |

REPOSITORIES: ENA

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Publications

Gut microbiota are related to Parkinson's disease and clinical phenotype.

Scheperjans Filip F   Aho Velma V   Pereira Pedro A B PA   Koskinen Kaisa K   Paulin Lars L   Pekkonen Eero E   Haapaniemi Elena E   Kaakkola Seppo S   Eerola-Rautio Johanna J   Pohja Marjatta M   Kinnunen Esko E   Murros Kari K   Auvinen Petri P  

Movement disorders : official journal of the Movement Disorder Society 20141205 3


In the course of Parkinson's disease (PD), the enteric nervous system (ENS) and parasympathetic nerves are amongst the structures earliest and most frequently affected by alpha-synuclein pathology. Accordingly, gastrointestinal dysfunction, in particular constipation, is an important non-motor symptom in PD and often precedes the onset of motor symptoms by years. Recent research has shown that intestinal microbiota interact with the autonomic and central nervous system via diverse pathways inclu  ...[more]

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