Project description:Glioneuronal tumor (GN) is one type of biphasic central nervous system (CNS) tumor that exhibits both glial and neuronal immunohistological characteristics. We report a case of glioneuronal tumor (GN) with a discovery of novel gene fusion of CLIP2-MET resulting from aberrant chromosome 7 abnormalities. The tumor exhibited typical characteristics on histological examinations. We executed an elaborate genomic study on this case including whole-exome sequencing and RNA sequencing. Genomic analysis of the tumor revealed aberrations in chromosomes 1 and 7 and a CLIP2-MET fusion. Further analysis of the upregulated genes revealed substantial connections with MAPK pathway activation. We concluded that the chromosome 7 abnormalities prompted CLIP2-MET gene fusion which successively leads to MAPK pathway activation. We deliberated that MAPK pathway activation is responsible for the oncogenesis of GN based on our case and other previously reported ones.

2019-12-28 | GSE142668 | GEO

Glioneuronal tumor with CLIP2-MET fusion: A case report

Project description:Glioneuronal tumor with CLIP2-MET fusion: A case report

| PRJNA597892 | ENA

Profiling immune network in regressing histiocytic dermatosis: a case report

Project description:Profiling immune network in regressing histiocytic dermatosis: a case report

| PRJNA800633 | ENA

Bovine Respiratory Syncytial virus: a case report

Project description:High Pathogenic Bovine Respiratory Syncytial virus variant in a breeding of milk bovine: a case report.

| PRJEB34143 | ENA

African Swine Fever in A Bulgarian Backyard Farm – A Case Report

Project description:African Swine Fever in A Bulgarian Backyard Farm – A Case Report