Meningococcal carriage 2021
Ontology highlight
ABSTRACT:
PROVIDER: PRJEB50085 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Swedish meningococcal carriage study performed in 2018-2019.
| PRJEB41190 | ENA
Project description:Meningococcal strains from different serogroups and different clonal complexes were compared using cGH analyses
2011-04-09 | GSE18078 | GEO
Project description:Meningococcal strains from different serogroups and different clonal complexes were compared using cGH analyses
2010-07-19 | GSE18158 | GEO
Project description:Meningococcal strains from different serogroups and different clonal complexes were compared using cGH analyses in a one color experiment.
2010-07-19 | GSE18159 | GEO
Project description:Secondary bacterial pneumonia following influenza infection is a significant cause of mortality worldwide. Upper respiratory tract pneumococcal carriage is important as both determinants of disease and population transmission. The immunological mechanisms that contain pneumococcal carriage are well-studied in mice but remain unclear in humans. Loss of this control of carriage following influenza infection is associated with secondary bacterial pneumonia during seasonal and pandemic outbreaks. We used a human type 6B pneumococcal challenge model to show that carriage acquisition induces early degranulation of resident neutrophils and recruitment of monocytes to the nose. Monocyte function associated with clearance of pneumococcal carriage. Prior nasal infection with live attenuated influenza virus induced inflammation, impaired innate function and altered genome-wide nasal gene responses to pneumococcal carriage. Levels of the cytokine IP-10 promoted by viral infection at the time of pneumococcal encounter was positively associated with bacterial density. These findings provide novel insights in nasal immunity to pneumococcus and viral-bacterial interactions during co-infection.
2018-07-25 | GSE117580 | GEO
Project description:The aims of the present study were to investigate the inflammatory responses in various organs as compared with the systemic circulation in an experimental porcine model of meningococcal sepsis using wild-type N. meningitidis; to study the role of LPS versus non-LPS microbial molecules as triggers of organ inflammation in meningococcal sepsis
2022-03-17 | GSE198668 | GEO
Project description:Background: We employed DNA microarray technology to investigate the host response to Streptococcus pneumoniae in a mouse model of asymptomatic carriage. Over a period of six weeks, we profiled transcript abundance and complexity in the Nasal Associated Lymphoid Tissue (NALT) to identify genes whose expression differed between pneumococcal-colonized and uncolonized states. Results: Colonization with S. pneumoniae altered the expression of hundreds of genes over the course of the study, demonstrating that carriage is a dynamic process characterized by increased expression of a set of early inflammatory responses, including induction of a Type 1 Interferon response, and the production of several antimicrobial factors. Subsequent to this initial inflammatory response, we observed increases in transcripts associated with T cell development and activation, as well as wounding, basement membrane remodeling, and cell proliferation. Our analysis suggests that microbial colonization induced expression of genes encoding components critical for controlling JAK/STAT signaling, including stat1, stat2, socs3, and mapk1, as well as induction of several Type 1 Interferon-inducible genes and other antimicrobial factors at the earliest stages of colonization. Conclusions: Examining multiple time points over six weeks of colonization demonstrated that asymptomatic carriage stimulates a dynamic host response characterized by temporal waves with distinct biological programs. Our data suggest that the usual response to the presence of the pneumocccus is an initial controlled inflammatory response followed by activation of host physiological processes such as response to wounding, basement membrane remodeling, and increasing cellular numbers that ultimately allow the host to maintain an intact epithelium and eventually mount a preventive adaptive immune response. A disease state experiment design type is where the state of some disease such as infection, pathology, syndrome, etc is studied.
2009-08-31 | GSE16803 | GEO
Project description:Meningococcal strains from different serogroups and different clonal complexes were compared using cGH analyses DNA isolated from the various strains were compared using a common reference design where the common reference comprised of a pool of all individual DNA´s.
2011-04-09 | E-GEOD-18078 | biostudies-arrayexpress
Project description:Meningococcal strains from different serogroups and different clonal complexes were compared using cGH analyses DNA isolated from the various strains were compared using a common reference design where the common reference comprised of a pool of all individual DNA´s.
2010-07-19 | E-GEOD-18158 | biostudies-arrayexpress
Project description:We performed systems analyses of immune responses to the meningococcal polysaccharide (MPSV4) and conjugate (MCV4) vaccines in healthy adults. The goal was to identify innate gene signatures that correlate to antibody responses induced by these vaccines.
2013-12-15 | GSE52245 | GEO