Project description:Comprehensive map of first- and second-trimester gonadal development in humans using a combination of single-cell and spatial transcriptomics, chromatin accessibility assays, and imaging.

2024-02-05 | E-MTAB-10570 | biostudies-arrayexpress

multiomic snRNAseq/snATACseq of first and second-trimester human gonads

2022-05-12 | E-MTAB-11708 | biostudies-arrayexpress

Spatial transcriptomics (Visium) of first and second-trimester human gonads

2022-05-03 | E-MTAB-10589 | biostudies-arrayexpress

RNA-seq of human first and second trimester placenta

Project description:The study compares expression differences between first and second trimester placenta in humans. RNA-Sequencing was performed on villi obtained at 7-8 (n=8) and 13-14 (n=6) weeks’ gestational age.

2021-06-02 | E-MTAB-9203 | biostudies-arrayexpress

Reconstructing the human first trimester fetal-maternal interface using single cell transcriptomics - 10x data

Project description:To explore the interactions between the range of maternal and fetal placental cell types present, we profiled the transcriptomes of more than 50,000 single cells from matched first trimester samples of maternal blood and decidua, as well as fetal cells from the placenta itself. RNA-seq was done using the standard 10x chromium v2 chemistry.

2018-10-02 | E-MTAB-6701 | biostudies-arrayexpress

RNA-seq of human first and second trimester placenta

Project description:RNA-seq of human first and second trimester placenta

| PRJEB38810 | ENA

Single-cell analysis of fetal human gonads (male and female) using 10X genomics

Project description:Single cell transcriptomic analyses are increasingly being employed to study human developmental processes in the gonad to advance our understanding of human gametogenesis. However, to date, these analyses have primarily focused on germ cells, while the somatic niche has been largely overlooked. Moreover, a comparative transcriptomic analysis of both female and male early gonad development on the single cell level is currently lacking. We performed single cell RNA-Seq on whole human fetal gonads from first and second trimester, both from male and female. We define gene expression profiles, which include novel marker genes, of major gonadal somatic cell types and validate them on the protein level. We identify the genetic signature of early human male rete cells, both in male and in female gonads. Overall, our study provides an in-depth molecular characterization of both male and female somatic cell types in early fetal gonads.

2024-01-02 | GSE181558 | GEO

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